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The Goldilocks Principle: A Unifying Perspective on Biochemical Adaptation to Abiotic Stressors in the Sea
Annual Review of Marine Science ( IF 14.3 ) Pub Date : 2022-01-03 , DOI: 10.1146/annurev-marine-022521-102228
George N Somero 1
Affiliation  

The ability of marine organisms to thrive over wide ranges of environmental stressors that perturb structures of proteins, nucleic acids, and lipids illustrates the effectiveness of adaptation at the biochemical level. A critical role of these adaptations is to achieve a proper balance between structural rigidity, which is necessary for maintaining three-dimensional conformation, and flexibility, which is required to allow changes in conformation during function. The Goldilocks principle refers to this balancing act, wherein structural stability and functional properties are poised at values that are just right for the environment the organism faces. Achieving this balance involves changes in macromolecular sequence and adaptive change in the composition of the aqueous or lipid milieu in which macromolecules function. This article traces the development of the field of biochemical adaptation throughout my career and shows how comparative studies of marine animals from diverse habitats have shed light on fundamental properties of life common to all organisms.

中文翻译:


金发姑娘原则:关于生物化学适应海洋非生物压力源的统一观点

海洋生物在扰乱蛋白质、核酸和脂质结构的各种环境压力源中茁壮成长的能力说明了在生化水平上适应的有效性。这些适应的一个关键作用是在结构刚性和柔韧性之间取得适当的平衡,这是维持三维构象所必需的,而柔韧性是在功能期间允许构象变化所必需的。金发姑娘原则指的是这种平衡行为,其中结构稳定性和功能特性处于适合有机体所面临环境的值。实现这种平衡涉及大分子序列的变化和大分子起作用的水性或脂质环境组成的适应性变化。

更新日期:2022-01-04
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