Chronic drug use is theorized to induce cortico-striatal neuroplasticity, driving an allostatic process marked by increased sensitivity to drug-related cues and decreased sensitivity to natural rewards that results in anhedonia and a dearth of positive affect. As such, positive emotion regulation represents a key mechanistic target for addictions treatment. This paper provides a conceptual model detailing how mindfulness may synergize a range of positive affective mechanisms to reduce addictive behavior, from savoring the hedonic pleasure derived from natural rewards, to self-generating interoceptive reward responses, and ultimately to cultivating self-transcendent meaning. These therapeutic processes may restructure reward processing from over-valuation of drug-related rewards back to valuation of natural rewards, and hypothetically, "reset" the default mode network dysfunction that undergirds addiction.

中文翻译：

---

正念积极情绪调节作为成瘾治疗：从享乐到自我超越的意义。

从理论上讲，慢性药物使用会诱导皮质纹状体神经可塑性，从而驱动一个平衡过程，其特点是对药物相关线索的敏感性增加，对自然奖励的敏感性降低，导致快感缺失和缺乏积极影响。因此，积极的情绪调节代表了成瘾治疗的关键机制目标。本文提供了一个概念模型，详细说明了正念如何协同一系列积极的情感机制来减少成瘾行为，从享受自然奖励带来的享乐，到自我产生的内感受性奖励反应，最终培养自我超越的意义。这些治疗过程可能会重组奖励过程，从对药物相关奖励的高估回归到对自然奖励的评估，假设，“