The Notch signaling pathway is an evolutionarily conserved pathway usually present in multicellular organisms, which plays a pivotal role in cell fate determination and proliferation. Due to this property, it is known to be highly oncogenic, especially in the dysregulated version of the Notch pathway, where apoptosis is inhibited and abnormal cell growth is supported. Notch receptors and ligand proteins play an essential role in cancers, such as myeloid leukemia, T-cell lymphoblastic leukemia, and organ-specific, i.e., breast, colon, pancreas, and skin cancers. Any type of cancer generates due to genetic defects, including epigenetic alterations and mutations. The researchers can use these alterations to find a promising diagnostic as well as therapeutic tool for cancer. The successful inhibition of the Notch pathway with the help of specific biomarkers or suppression of gene expression represents a new remedy in cancer research. This article focuses on the various remedies hidden within the Notch pathway's mechanism, primarily based on different patents published in recent years for assisting cancer diagnosis and succeeding treatment.

中文翻译：

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癌症诊断和治疗中的靶向 Notch 通路：一种新兴方法。

Notch信号通路是一种进化上保守的通路，通常存在于多细胞生物中，在细胞命运决定和增殖中起关键作用。由于这种特性，已知它具有高度致癌性，特别是在 Notch 通路的失调版本中，其中细胞凋亡被抑制并支持异常细胞生长。Notch 受体和配体蛋白在癌症（例如髓性白血病、T 细胞淋巴细胞白血病）和器官特异性（即乳腺癌、结肠癌、胰腺癌和皮肤癌）中发挥重要作用。任何类型的癌症都是由于遗传缺陷而产生的，包括表观遗传改变和突变。研究人员可以利用这些改变来找到一种有前途的癌症诊断和治疗工具。在特定生物标志物的帮助下成功抑制 Notch 通路或抑制基因表达代表了癌症研究的新疗法。本文重点介绍隐藏在 Notch 通路机制中的各种补救措施，主要基于近年来公布的用于辅助癌症诊断和后续治疗的不同专利。