This article proposes a model for understanding the effects of adverse childhood experiences (ACEs) as dynamic and interrelated biobehavioral adaptations to early life stress that have predictable consequences on development and health. Drawing upon research from multiple theoretical and methodological approaches, the intergenerational and cumulative adverse and resilient experiences (ICARE) model posits that the negative consequences of ACEs result from biological and behavioral adaptations to adversity that alter cognitive, social, and emotional development. These adaptations often have negative consequences in adulthood and may be transmitted to subsequent generations through epigenetic changes as well as behavioral and environmental pathways. The ICARE model also incorporates decades of resilience research documenting the power of protective relationships and contextual resources in mitigating the effects of ACEs. Examples of interventions are provided that illustrate the importance of targeting the dysregulated biobehavioral adaptations to ACEs and developmental impairments as well as resulting problem behaviors and health conditions. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

---

整合和综合逆境和复原力知识和行动：ICARE 模型。

本文提出了一个模型，用于理解不良童年经历 (ACE) 的影响，将其视为对早期生活压力的动态且相互关联的生物行为适应，对发育和健康产生可预测的后果。借鉴多种理论和方法论的研究，代际和累积的逆境和弹性经历（ICARE）模型认为，ACE 的负面后果是由于对逆境的生物和行为适应而导致的，从而改变了认知、社会和情感的发展。这些适应通常会在成年后产生负面影响，并可能通过表观遗传变化以及行为和环境途径传递给后代。ICARE 模型还结合了数十年的复原力研究，记录了保护关系和情境资源在减轻 ACE 影响方面的力量。提供的干预措施示例说明了针对 ACE 失调的生物行为适应和发育障碍以及由此产生的问题行为和健康状况的重要性。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。