Addiction is a chronic and potentially deadly disease considered a global health problem. Nevertheless, there is still no ideal treatment for its management. The alterations in the reward system are the most known pathophysiological mechanisms. Dopamine is the pivotal neurotransmitter involved in neuronal drug reward mechanisms and its neuronal mechanisms have been intensely investigated in recent years. However, neuroglial interactions and their relation to drug addiction development and maintenance of drug addiction have been understudied. Many reports have found that most neuroglial cells express dopamine receptors and that dopamine activity may induce neuroimmunomodulatory effects. Furthermore, current research has also shown that pro- and anti-inflammatory molecules modulate dopaminergic neuron activity. Thus, studying the immune mechanisms of dopamine associated with drug abuse is vital in researching new pathophysiological mechanisms and new therapeutic targets for addiction management.

成瘾是一种慢性且可能致命的疾病，被认为是全球健康问题。尽管如此，其管理仍然没有理想的治疗方法。奖赏系统的改变是最广为人知的病理生理机制。多巴胺是参与神经元药物奖励机制的关键神经递质，近年来对其神经元机制进行了深入研究。然而，神经胶质相互作用及其与药物成瘾发展和维持药物成瘾的关系尚未得到充分研究。许多报道发现，大多数神经胶质细胞表达多巴胺受体，多巴胺活性可能诱导神经免疫调节作用。此外，目前的研究还表明，促炎和抗炎分子可以调节多巴胺能神经元的活性。因此，