Tissue regeneration is regulated by the cellular microenvironment, e.g. the extracellular matrix. Here, sulfated glycosaminoglycans (GAG), are of vital importance interacting with mediator proteins and influencing their biological activity. Hence, they are promising candidates for controlling tissue regeneration. This review addresses recent achievements regarding chemically modified GAG as well as collagen/GAG-based coatings and hydrogels including (i) chemical functionalization strategies for native GAG, (ii) GAG-based biomaterial strategies for controlling cellular responses, (iii) (bio)chemical methods for characterization and iv) protein interaction profiles and attained tissue regeneration in vitro and in vivo. The potential of GAG for bioinspired, functional biomaterials is highlighted.

中文翻译：

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化学改性的糖胺聚糖衍生物作为生物材料涂层和水凝胶的组成部分

组织再生受细胞微环境调节，例如细胞外基质。在这里，硫酸化糖胺聚糖 (GAG) 与介质蛋白相互作用并影响其生物活性至关重要。因此，它们是控制组织再生的有希望的候选者。本综述阐述了关于化学改性 GAG 以及基于胶原蛋白/GAG 的涂层和水凝胶的最新成就，包括 (i) 天然 GAG 的化学功能化策略，(ii) 基于 GAG 的用于控制细胞反应的生物材料策略，(iii) (生物)表征和 iv) 蛋白质相互作用谱和获得的组织再生的化学方法体外和体内. 强调了 GAG 在仿生功能性生物材料方面的潜力。