BACKGROUND Patients with peripheral arterial disease (PAD) are generally less intensively managed than patients with coronary heart disease (CHD), despite that their risk of complications is believed to be equivalent. Identification of PAD patients at risk of poorly controlled blood pressure (BP) could lead to improved treatment, thus lowering the risk of cardiovascular (CV) complications. We aimed to describe the prevalence of poorly controlled cardiovascular (CV) risk factors, focusing on BP, in outpatients with PAD diagnosed in a vascular ultrasound laboratory. METHODS Consecutive outpatients with carotid and/or lower extremity PAD were included (n = 402) and examined with blood sampling, clinical BP, and 24-h ambulatory BP measurements. A poorly controlled clinical BP was defined as ≥140/90 mmHg, ambulatory BP ≥130/80 mmHg, low-density lipoprotein (LDL)-cholesterol level ≥2.5 mmol/L, and glycated hemoglobin (HbA1c) level >53 mmol/mol in those with diabetes. RESULTS Most of the patients had poorly controlled clinical (76.6%) and ambulatory BP (51.7%) profiles. Antihypertensive medications were prescribed in 84% of the patients. However, >40% of them used only 0-1 medication, and <25% of them used three or more agents. Clinical BP, a low number of medications, body mass index, and the presence of diabetes independently predicted a poorly controlled ambulatory BP. Nearly one-third of the patients were smokers, and most of the cohort had an LDL-cholesterol level of ≥2.5 mmol/L. An HbA1c level of >53 mmol/mol was present in 55% of diabetic patients. CONCLUSION Poorly controlled clinical and ambulatory systolic BP profiles were common. In addition, suboptimal control of other important CV risk factors was detected. The findings of this study highlight the need for better preventive efforts against CV risk factors in outpatients with PAD.

中文翻译：

---

外周动脉疾病门诊患者动态血压控制不佳。

背景技术患有外周动脉疾病（PAD）的患者通常比患有冠心病（CHD）的患者的管理强度低，尽管他们的并发症风险被认为是相当的。识别有血压控制不佳 (BP) 风险的 PAD 患者可以改善治疗，从而降低心血管 (CV) 并发症的风险。我们的目的是描述在血管超声实验室诊断为 PAD 的门诊患者中控制不良的心血管 (CV) 危险因素的患病率，重点是 BP。方法 包括颈动脉和/或下肢 PAD 的连续门诊患者（n = 402），并通过采血、临床血压和 24 小时动态血压测量进行检查。控制不佳的临床血压定义为≥140/90 mmHg，动态血压≥130/80 mmHg，糖尿病患者的低密度脂蛋白（LDL）-胆固醇水平≥2.5 mmol/L，糖化血红蛋白（HbA1c）水平>53 mmol/mol。结果 大多数患者的临床（76.6%）和动态血压（51.7%）控制不佳。84% 的患者服用了抗高血压药物。然而，>40% 的人仅使用 0-1 种药物，<25% 的人使用三种或更多药物。临床血压、药物数量少、体重指数和糖尿病的存在独立地预测了控制不佳的动态血压。近三分之一的患者是吸烟者，大多数队列的低密度脂蛋白胆固醇水平≥2.5 mmol/L。55% 的糖尿病患者 HbA1c 水平 >53 mmol/mol。结论 控制不佳的临床和动态收缩压曲线很常见。此外，检测到其他重要 CV 风险因素的控制不佳。这项研究的结果强调需要更好地预防 PAD 门诊患者的心血管风险因素。