Current Organic Synthesis ( IF 1.8 ) Pub Date : 2021-10-31 , DOI: 10.2174/1570179418666210512015725 Thoraya Farghaly 1 , Alaa M Abo Alnaja 2 , Mohamed R Shaaban 1
β-Amino-α,β-enones or β-enamino carbonyl compounds are versatile synthons intermediates for the construction of various bio-active heterocyclic compounds and have been established as multipurpose synthetic precursors in organic syntheses and in pharmaceutical developments. In this work, we will discuss the different synthetic routes to obtain β−amino−α,β-enones or β-enamino carbonyl compounds, their reactions, and their utility in the construction of organic frameworks and heterocyclic ring systems. Structurally, β- amino-α,β-enones are attractive intermediates that syndicate the ambident behaviours of nucleophilicity and electrophilicity of enones at the same time. β-amino-α,β-enones have been known as acceptors in both 1,2- and 1,4- additions that make them good intermediate compounds for annulation to different heterocycles.
中文翻译:
β-氨基-α,β-烯酮(Enaminones)的合成与反应新进展
β-氨基-α,β-烯酮或 β-烯氨基羰基化合物是用于构建各种生物活性杂环化合物的通用合成子中间体,已被确定为有机合成和药物开发中的多用途合成前体。在这项工作中,我们将讨论获得 β-氨基-α、β-烯酮或 β-烯氨基羰基化合物的不同合成路线、它们的反应以及它们在构建有机骨架和杂环系统中的用途。在结构上,β-氨基-α,β-烯酮是有吸引力的中间体,它同时具有烯酮的亲核性和亲电性的双重行为。β-氨基-α,β-烯酮在 1,2- 和 1,4- 加成中都被认为是受体,这使它们成为与不同杂环成环的良好中间化合物。