Dear Editor: We have read with a great interest the article by Gupta et al. [1] who performed a meta-analysis exploring the association between chronic mechanical irritation and oral squamous cell carcinoma. The conclusion of the meta-analysis is that chronic oral mucosa irritation has a significant association with oral squamous cell carcinoma, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor. Read more in PDF.

中文翻译：

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关于“慢性机械刺激和口腔鳞状细胞癌：系统评价和荟萃分析”的信函。

亲爱的编辑：我们怀着极大的兴趣阅读了 Gupta 等人的文章。[1] 谁进行了一项荟萃分析，探索慢性机械刺激与口腔鳞状细胞癌之间的关联。荟萃分析的结论是，慢性口腔黏膜刺激与口腔鳞状细胞癌有显着关联，关联的性质可能是一个潜在的辅助因素（依赖风险因素），而不是一个独立的风险因素。在 PDF 中阅读更多内容。