Knowledge of the participation of ATP and related purines in urinary tract physiology has been established over the last five decades through the work of many independent groups, inspired by, and building on the pioneering studies of Professor Geoffrey Burnstock and his coworkers. As part of a series of reviews in this tribute edition, the present article summarises our current understanding of purines and purinergic signalling in modulating and regulating urinary tract function. Purinergic mechanisms underlying the origin of bladder pain; sensations of bladder filling and urinary tract motility; and regulation of detrusor smooth muscle contraction are described, encompassing the relevant history of discovery and consolidation of knowledge as methodologies and pharmacological tools have developed. We consider normal physiology, including development and aging and then move to pathophysiology, discussing the causal and consequential contribution of purinergic signalling mechanism and their constituent components (receptors, signal transduction, effector molecules) to bladder dysfunction.

在过去 5 年中，受 Geoffrey Burnstock 教授及其同事的开创性研究的启发和建立，通过许多独立团体的工作，已经建立了 ATP 和相关嘌呤参与泌尿道生理学的知识。作为本致敬版中一系列评论的一部分，本文总结了我们目前对嘌呤和嘌呤能信号在调节和调节尿路功能中的理解。膀胱疼痛起源的嘌呤能机制；膀胱充盈和尿路运动的感觉；描述了逼尿肌平滑肌收缩的调节和调节，包括随着方法学和药理学工具的发展而发现和巩固知识的相关历史。我们考虑正常的生理，