This article reports on the lived experience of Medtronic advanced hybrid closed-loop (AHCL) in comparison to first generation hybrid closed-loop (HCL) in a randomized, open-label, two-period crossover trial. Patient-reported outcome (PROs) measures were administered before randomization and at the end of each study period in 113 adolescents and young adults with type 1 diabetes. Glucose monitoring satisfaction subscales for emotional burden and behavioral burden improved significantly (P < 0.01) over time with use of AHCL versus HCL and co-occurred with glycemic improvements (reduced percent time above 180 mg/dL during the day and no change in % time less than 54 mg/dL across 24 h) and greater time in Auto Mode. PROs, including distress, technology attitudes, and hypoglycemia confidence, were not different. AHCL use was associated with improved glucose monitoring satisfaction. Satisfaction was greater in those participants who had more appreciable glycemic benefit and stayed in Auto Mode more often.

中文翻译：

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高级混合闭环与混合闭环的实际经验：患者报告的结果和观点

本文报告了美敦力高级混合闭环 (AHCL) 与第一代混合闭环 (HCL) 在随机、开放标签、两期交叉试验中的实际经验。在随机化之前和每个研究期结束时，对 113 名患有 1 型糖尿病的青少年和年轻人进行了患者报告结果 (PROs) 测量。情绪负担和行为负担的血糖监测满意度分量表显着改善（P < 0.01) 随着时间的推移，使用 AHCL 与 HCL 相比，并与血糖改善同时发生（白天超过 180 mg/dL 的时间百分比减少，24 小时内低于 54 mg/dL 的时间百分比没有变化）和更长的时间自动模式。PROs，包括痛苦、技术态度和低血糖信心，没有不同。AHCL 的使用与血糖监测满意度的提高有关。那些具有更明显的血糖益处并且更经常保持自动模式的参与者的满意度更高。