In colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC) and gastric cancer (GC) multiple studies of inter-tumor heterogeneity have identified molecular subtypes, which correlate with clinical features.

Our aim was to investigate the attributes of molecular subtypes across three different gastrointestinal cancer types. We performed a systematic search for publications on molecular subtypes or classifications in PDAC and GC and compared the described subtypes with the established consensus molecular subtypes of CRC.

Examining the characteristics of subtypes across CRC, PDAC and GC resulted in four categories of subtypes. We describe uniting and distinguishing features within a mesenchymal, an epithelial, an immunogenic and a metabolic and digestive subtype category.

We conclude that molecular subtypes of CRC, PDAC and GC display relevant overlap in molecular features and clinical outcomes. This finding encourages quantitative studies on subtypes across different cancer types and could lead to a paradigm shift in future treatment strategies.

在结直肠癌 (CRC)、胰腺导管腺癌 (PDAC) 和胃癌 (GC) 中，对肿瘤间异质性的多项研究已经确定了与临床特征相关的分子亚型。

我们的目的是研究三种不同胃肠道癌症类型的分子亚型的属性。我们对 PDAC 和 GC 中分子亚型或分类的出版物进行了系统搜索，并将所描述的亚型与 CRC 的既定共识分子亚型进行了比较。

检查跨 CRC、PDAC 和 GC 的亚型特征，得出了四类亚型。我们描述了间充质、上皮、免疫原性以及代谢和消化亚型类别中的统一和区分特征。

我们得出结论，CRC、PDAC 和 GC 的分子亚型在分子特征和临床结果方面显示出相关的重叠。这一发现鼓励对不同癌症类型的亚型进行定量研究，并可能导致未来治疗策略的范式转变。