Angiogenesis, hematopoiesis and osteogenesis are fundamental processes mediating complex and essential biological functions. In the bone marrow, endothelial cells (ECs) are a principal mediator of regulatory signals that govern hematopoietic and mesenchymal stem cells. EC and osteoblast interactions and niche functions of ECs are fundamental in maintaining bone health and coordinating repair and regeneration following injury. These cellular interactions are subject to dysregulation and deterioration under stress, aging, chronic disease states and malignancy. Thus, the prospect of manipulating the bone vasculature has tremendous potential to advance therapeutic interventions for the management of bone diseases. This review discusses the current state of vascular-skeletal tissue interactions focusing on osteoblast and hematopoietic stem cells interaction with ECs.

血管生成、造血和骨生成是介导复杂且重要的生物功能的基本过程。在骨髓中，内皮细胞 (EC) 是控制造血干细胞和间充质干细胞的调节信号的主要介质。 EC 和成骨细胞的相互作用以及 EC 的生态位功能对于维持骨骼健康和协调损伤后的修复和再生至关重要。这些细胞相互作用在压力、衰老、慢性疾病状态和恶性肿瘤的情况下会出现失调和恶化。因此，操纵骨脉管系统的前景对于推进骨疾病的治疗干预具有巨大的潜力。本综述讨论了血管-骨骼组织相互作用的现状，重点关注成骨细胞和造血干细胞与 EC 的相互作用。