Medical & Biological Engineering & Computing ( IF 2.6 ) Pub Date : 2021-07-17 , DOI: 10.1007/s11517-021-02404-z Farideh Mohammadi 1 , Farzaneh Mohammadi 2, 3, 4 , Zeynab Yavari 5
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Electrospun nanofibrous membrane (ENM) is a membrane fabricated using electrospinning technique which has considerable characteristics such as high porosity, nanometer pore size, and simple process. Although ENMs are being evaluated in various medical applications, the effectiveness for hemodialysis (HD) has not been evaluated carefully. Thus, in this study, the cylindrical electrospun nanofibrous polysulfone (CENP) membrane was fabricated and its performance in the dialysis adequacy in HD patients was evaluated.
The CENP membrane was fabricated in a tabular shape. The physical characteristics of the membrane are examined using scanning electron microscope (SEM) images and the permporometry technique. Then, its efficiency in urea and creatinine removal from the blood serum of 21 HD patients was evaluated at a low blood flow rate (BFR) of 200 ml min-1 and dialysate fluid rate (DFR) of 300 ml min-1. Afterwards, the results were modeled and optimized using artificial neural network (ANN) and genetic algorithm (GA), respectively. Finally, sensitive analysis was performed via Spearman’s rank correlation coefficient. The highest dialysis adequacy was observed in membranes with an inner diameter of 3 mm. The CENP membrane belongs to the super high-flux membrane and it could be replaced with existing commercial hollow fiber membranes.
Graphical abstract
中文翻译：
用建模方法表征用于血液透析的圆柱形电纺纳米纤维聚砜膜
静电纺纳米纤维膜（ENM）是一种采用静电纺丝技术制造的膜，具有孔隙率高、孔径纳米、工艺简单等特点。尽管 ENM 正在各种医学应用中进行评估，但尚未仔细评估血液透析 (HD) 的有效性。因此，在这项研究中，制造了圆柱形电纺纳米纤维聚砜 (CENP) 膜，并评估了其在 HD 患者透析充分性方面的性能。
CENP 膜被制成板状。使用扫描电子显微镜 (SEM) 图像和渗透测量技术检查膜的物理特性。然后，其在从21名HD患者血清尿素和肌酸酐清除效率在低血流量为200毫升分钟（BFR）评价-1 300毫升分钟和透析液率（DFR）-1. 然后，分别使用人工神经网络（ANN）和遗传算法（GA）对结果进行建模和优化。最后，通过斯皮尔曼等级相关系数进行敏感性分析。在内径为 3 毫米的膜中观察到最高的透析充分性。CENP膜属于超高通量膜，可以替代现有的商用中空纤维膜。
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