As the earliest studied epigenetic modification, acetylation has been explored a lot through the years. While bone tissue acts as an indispensable part of body, researches aimed at the relationship between the bone and acetylation became necessary. Some environmental factors like diet may affect the metabolism status that some metabolites especially nicotinamide adenine dinucleotide (NAD) were found able to regulate intracellular histone acetylation in bone metabolism. This review focuses on representing the interaction among acetylation, metabolism, and the bone. The results showed that acetylation connects a lot with bone metabolism, while the explorations about related metabolites like acetyl-CoA or different environmental exposures are still limited. Some acetylation-related therapy methods of bone diseases based on metabolic regulation or epigenetic enzymes were also reviewed.

中文翻译：

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骨代谢和相关疾病表观遗传调控中的组蛋白乙酰化

作为最早研究的表观遗传修饰，多年来对乙酰化进行了大量探索。虽然骨组织是身体不可或缺的一部分，但有必要针对骨骼与乙酰化之间的关系进行研究。一些环境因素如饮食可能会影响代谢状态，发现某些代谢物，尤其是烟酰胺腺嘌呤二核苷酸 (NAD) 能够调节骨代谢中的细胞内组蛋白乙酰化。本综述重点介绍乙酰化、代谢和骨骼之间的相互作用。结果表明乙酰化与骨代谢密切相关，而对乙酰辅酶A或不同环境暴露等相关代谢物的探索仍然有限。