Historically, non-seminomatous germ cell tumor (NSGCT) has been considered a radio-resistant disease, excluding radiotherapy (RT) from curative strategies. However, case series exploring the use of radiation treatment in this setting are often outdated, and prospective ongoing studies testing new radiotherapeutic approaches in NSGCT are lacking. Considering that tremendous advances in radiotherapy technology have enabled improved precision in RT delivery as well as dose escalation while decreasing treatment-related morbidity, we overviewed the currently available literature to explore the radiobiological basis, the technical issues, and potential strategies for implementation of RT in the management of this clinical entity. The purpose of the present overview is to provide insight for future research in this unexplored scenario. In summary, the biological rationale for RT use and potential implementation with systemic therapies exist, especially considering the advantage of new technologies, which were unavailable in the era of early literature reports. The NSGCT radioresistance paradigm could be based only on the fact that effective treatment schedules were simply undeliverable with older RT techniques due to toxicity issues, but the availability of actual techniques may prompt further exploration to offer treatment alternatives to these patients. Ongoing trials on this issue are lacking, but potential areas of research are platinum-refractory disease and consolidation therapy for residual masses after PST.

从历史上看，非精原细胞生殖细胞肿瘤 (NSGCT) 被认为是一种抗放射疾病，将放射治疗 (RT) 排除在治疗策略之外。然而，探索在这种情况下使用放射治疗的病例系列通常已经过时，并且缺乏在 NSGCT 中测试新放射治疗方法的前瞻性研究。考虑到放射治疗技术的巨大进步提高了放疗和剂量递增的精确度，同时降低了治疗相关的发病率，我们概述了目前可用的文献，以探索放射生物学基础、技术问题和在放疗中实施放疗的潜在策略该临床实体的管理。本概述的目的是为未来在这种未经探索的情况下的研究提供见解。总之，使用放疗的生物学原理和全身疗法的潜在实施是存在的，特别是考虑到新技术的优势，而这些优势在早期文献报道时代是不可用的。NSGCT 放射抗性范式可能仅基于这样一个事实，即由于毒性问题，旧的 RT 技术根本无法提供有效的治疗计划，但实际技术的可用性可能会促使进一步探索为这些患者提供治疗替代方案。缺乏关于这个问题的正在进行的试验，但潜在的研究领域是铂类难治性疾病和 PST 后残留肿块的巩固治疗。这在早期文献报道时代是无法获得的。NSGCT 放射抗性范式可能仅基于这样一个事实，即由于毒性问题，旧的 RT 技术根本无法提供有效的治疗计划，但实际技术的可用性可能会促使进一步探索为这些患者提供治疗替代方案。缺乏关于这个问题的正在进行的试验，但潜在的研究领域是铂类难治性疾病和 PST 后残留肿块的巩固治疗。这在早期文献报道时代是无法获得的。NSGCT 放射抗性范式可能仅基于这样一个事实，即由于毒性问题，旧的 RT 技术根本无法提供有效的治疗计划，但实际技术的可用性可能会促使进一步探索为这些患者提供治疗替代方案。缺乏关于这个问题的正在进行的试验，但潜在的研究领域是铂类难治性疾病和 PST 后残留肿块的巩固治疗。