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Relating quantitative 7T MRI across cortical depths to cytoarchitectonics, gene expression and connectomics
Human Brain Mapping ( IF 3.5 ) Pub Date : 2021-07-17 , DOI: 10.1002/hbm.25595 Peter McColgan 1, 2 , Saskia Helbling 1 , Lenka Vaculčiaková 1 , Kerrin Pine 1 , Konrad Wagstyl 3 , Fakhereh Movahedian Attar 1 , Luke Edwards 1 , Marina Papoutsi 2 , Yongbin Wei 4 , Martijn Pieter Van den Heuvel 4 , Sarah J Tabrizi 2 , Geraint Rees 3 , Nikolaus Weiskopf 1, 5
Human Brain Mapping ( IF 3.5 ) Pub Date : 2021-07-17 , DOI: 10.1002/hbm.25595 Peter McColgan 1, 2 , Saskia Helbling 1 , Lenka Vaculčiaková 1 , Kerrin Pine 1 , Konrad Wagstyl 3 , Fakhereh Movahedian Attar 1 , Luke Edwards 1 , Marina Papoutsi 2 , Yongbin Wei 4 , Martijn Pieter Van den Heuvel 4 , Sarah J Tabrizi 2 , Geraint Rees 3 , Nikolaus Weiskopf 1, 5
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Ultra-high field MRI across the depth of the cortex has the potential to provide anatomically precise biomarkers and mechanistic insights into neurodegenerative disease like Huntington's disease that show layer-selective vulnerability. Here we compare multi-parametric mapping (MPM) measures across cortical depths for a 7T 500 μm whole brain acquisition to (a) layer-specific cell measures from the von Economo histology atlas, (b) layer-specific gene expression, using the Allen Human Brain atlas and (c) white matter connections using high-fidelity diffusion tractography, at a 1.3 mm isotropic voxel resolution, from a 300mT/m Connectom MRI system. We show that R2*, but not R1, across cortical depths is highly correlated with layer-specific cell number and layer-specific gene expression. R1- and R2*-weighted connectivity strength of cortico-striatal and intra-hemispheric cortical white matter connections was highly correlated with grey matter R1 and R2* across cortical depths. Limitations of the layer-specific relationships demonstrated are at least in part related to the high cross-correlations of von Economo atlas cell counts and layer-specific gene expression across cortical layers. These findings demonstrate the potential and limitations of combining 7T MPMs, gene expression and white matter connections to provide an anatomically precise framework for tracking neurodegenerative disease.
中文翻译：
将皮质深度的定量 7T MRI 与细胞结构、基因表达和连接组学联系起来
跨越皮质深度的超高场 MRI 有可能为神经退行性疾病（如亨廷顿病）提供解剖学上精确的生物标志物和机制见解，这些疾病显示出层选择性的脆弱性。在这里，我们使用 Allen 模型将 7T 500 μm 全脑采集的跨皮质深度的多参数映射 (MPM) 测量值与 (a) von Economo 组织学图谱中的层特定细胞测量值、(b) 层特定基因表达进行比较使用来自 300mT/m Connectom MRI 系统的高保真扩散纤维束成像技术以 1.3 毫米各向同性体素分辨率绘制人脑图谱和 (c) 白质连接。我们发现，整个皮质深度的 R2*（而非 R1）与层特异性细胞数量和层特异性基因表达高度相关。皮质纹状体和半球内皮质白质连接的 R1 和 R2* 加权连接强度与整个皮质深度的灰质 R1 和 R2* 高度相关。所证明的层特异性关系的局限性至少部分与 von Economo 图谱细胞计数和跨皮质层的层特异性基因表达的高度互相关性有关。这些发现证明了将 7T MPM、基因表达和白质连接结合起来为跟踪神经退行性疾病提供解剖学上精确的框架的潜力和局限性。
更新日期：2021-09-19
中文翻译：
将皮质深度的定量 7T MRI 与细胞结构、基因表达和连接组学联系起来
跨越皮质深度的超高场 MRI 有可能为神经退行性疾病（如亨廷顿病）提供解剖学上精确的生物标志物和机制见解，这些疾病显示出层选择性的脆弱性。在这里，我们使用 Allen 模型将 7T 500 μm 全脑采集的跨皮质深度的多参数映射 (MPM) 测量值与 (a) von Economo 组织学图谱中的层特定细胞测量值、(b) 层特定基因表达进行比较使用来自 300mT/m Connectom MRI 系统的高保真扩散纤维束成像技术以 1.3 毫米各向同性体素分辨率绘制人脑图谱和 (c) 白质连接。我们发现，整个皮质深度的 R2*（而非 R1）与层特异性细胞数量和层特异性基因表达高度相关。皮质纹状体和半球内皮质白质连接的 R1 和 R2* 加权连接强度与整个皮质深度的灰质 R1 和 R2* 高度相关。所证明的层特异性关系的局限性至少部分与 von Economo 图谱细胞计数和跨皮质层的层特异性基因表达的高度互相关性有关。这些发现证明了将 7T MPM、基因表达和白质连接结合起来为跟踪神经退行性疾病提供解剖学上精确的框架的潜力和局限性。
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