Human behavior in social dilemmas is strongly framed by the social context, but the mechanisms underlying this framing effect remains poorly understood. To identify the behavioral and neural responses mediating framing of social interactions, subjects underwent functional Magnetic Resonance Imaging while playing a Prisoners Dilemma game. In separate neuroimaging sessions, the game was either framed as a cooperation game or a competition game. Social decisions where subjects were affected by the frame engaged the hippocampal formation, precuneus, dorsomedial prefrontal cortex and lateral temporal gyrus. Among these regions, the engagement of the left hippocampus was further modulated by individual differences in empathy. Social decisions not adhering to the frame were associated with stronger engagement of the angular gyrus and trend increases in lateral orbitofrontal cortex, posterior intraparietal cortex, and temporopolar cortex. Our findings provide the first insight into the mechanisms underlying framing of behavior in social dilemmas, indicating increased engagement of the hippocampus and neocortical areas involved in memory, social reasoning and mentalizing when subjects make decisions that conform to the imposed social frame.

中文翻译：

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社会困境中框架效应的神经基础。

社会困境中的人类行为受到社会背景的强烈限制，但这种框架效应背后的机制仍然知之甚少。为了识别介导社交互动框架的行为和神经反应，受试者在玩囚徒困境游戏时接受了功能性磁共振成像。在单独的神经影像学会议中，游戏要么被定义为合作游戏，要么被定义为竞争游戏。受试者受框架影响的社会决策涉及海马结构、楔前叶、背内侧前额叶皮层和颞外侧回。在这些区域中，同理心的个体差异进一步调节了左侧海马体的参与。不遵守框架的社会决策与角回的更强接合和外侧眶额叶皮层、后顶内皮层和颞极皮层的趋势增加有关。我们的研究结果首次洞察了社会困境中行为框架的机制，表明当受试者做出符合强加的社会框架的决定时，海马体和新皮质区域参与记忆、社会推理和心智化的程度增加。