Abstract The increased availability and use of botanical dietary supplements (BDS) has been accompanied by an increased frequency of adulteration of these products with pharmaceutical chemicals. These adulterated products are a worldwide problem, and their consumption poses health risks to consumers. The main focus of this paper is to highlight novel screening approaches utilized in the detection of adulterants in BDS marketed for different therapeutic purposes. We summarize spectroscopic methods involving near-infrared, infrared, Raman, and nuclear magnetic resonance spectroscopy as feasible and interesting in-field screening tools for the analysis of suspected products (adulterated or not) before being sent to a laboratory for deeper inspection. In addition, the new approaches based on chromatographic methods such as liquid chromatography-circular dichroism, liquid chromatography-mass spectrometry, thin layer chromatography-surface enhanced Raman spectroscopy, and thin layer chromatography-mass spectrometry are discussed and reviewed. Novel analysis strategies from targeted analysis to post-targeted and non-targeted analysis allowing simultaneous determination of the number of multiclass pharmaceuticals are discussed.

中文翻译：

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植物膳食补充剂中掺假的药物化学品：新的筛选方法

摘要 随着植物性膳食补充剂 (BDS) 的可用性和使用量的增加，这些产品中掺入药物化学品的频率增加。这些掺假产品是一个世界性问题，它们的消费对消费者构成健康风险。本文的主要重点是强调用于检测 BDS 中用于不同治疗目的的掺假物的新型筛查方法。我们总结了涉及近红外、红外、拉曼和核磁共振光谱的光谱方法，将其作为可行且有趣的现场筛选工具，用于在被送到实验室进行更深入检查之前分析可疑产品（是否掺假）。此外，对基于液相色谱-圆二色色谱、液相色谱-质谱、薄层色谱-表面增强拉曼光谱和薄层色谱-质谱等色谱方法的新方法进行了讨论和综述。讨论了从靶向分析到靶向后和非靶向分析的新分析策略，允许同时确定多类药物的数量。