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Recent developments in microfluidic paper-, cloth-, and thread-based electrochemical devices for analytical chemistry
Reviews in Analytical Chemistry ( IF 3.6 ) Pub Date : 2017-07-14 , DOI: 10.1515/revac-2016-0018
Radha S.P. Malon , Lee Yook Heng , Emma P. Córcoles

Abstract The attractive structural and mechanical properties of cellulose substrates (paper, cloth, and thread), including passive fluid transport, biocompatibility, durability, and flexibility, have attracted researchers in the past few decades to explore them as alternative microfluidic platforms. The incorporation of electrochemical (EC) sensing broadened their use for applications such as clinical diagnosis, pharmaceutical chemical analyses, food quality, and environmental monitoring. This article provides a review on the microfluidic devices constructed on paper, cloth, and thread substrates. It begins with an overview on paper-based microfluidic devices, followed by an in-depth review on the various applications of EC detection incorporated on paper-based microfluidic devices reported to date. The review on paper-based microfluidic devices attempts to convey a few perspective directions that cloth- and thread-based microfluidic devices may take in its development. Finally, the research efforts on the development and evaluation, as well as current limitations of cloth- and thread-based microfluidic devices are discussed. Microfluidic devices constructed on paper, cloth, and thread substrates are still at an early development stage (prototype) requiring several improvements in terms of fabrication, analytical techniques, and performance to become mature platforms that can be adapted and commercialized as real world products. However, they hold a promising potential as wearable devices.

中文翻译:

用于分析化学的微流体纸、布和线基电化学装置的最新进展

摘要 纤维素基材(纸、布和线)具有吸引人的结构和机械特性,包括被动流体传输、生物相容性、耐用性和柔韧性,在过去的几十年里吸引了研究人员将其作为替代微流体平台进行探索。电化学 (EC) 传感的结合扩大了它们在临床诊断、药物化学分析、食品质量和环境监测等应用中的应用。本文综述了在纸、布和线基材上构建的微流体装置。它首先概述了纸基微流体设备,然后深入回顾了迄今为止报道的纸基微流体设备中包含的 EC 检测的各种应用。对基于纸的微流体设备的评论试图传达基于布料和线的微流体设备在其发展中可能采取的一些透视方向。最后,讨论了开发和评估的研究工作,以及基于布料和线的微流体装置的当前局限性。在纸、布和线基材上构建的微流体设备仍处于早期开发阶段(原型),需要在制造、分析技术和性能方面进行多项改进,以成为可以作为现实世界产品进行调整和商业化的成熟平台。然而,它们作为可穿戴设备具有很大的潜力。讨论了开发和评估的研究工作,以及基于布料和线的微流体设备的当前局限性。在纸、布和线基材上构建的微流体设备仍处于早期开发阶段(原型),需要在制造、分析技术和性能方面进行多项改进,以成为可以作为现实世界产品进行调整和商业化的成熟平台。然而,它们作为可穿戴设备具有很大的潜力。讨论了开发和评估的研究工作,以及基于布料和线的微流体设备的当前局限性。在纸、布和线基材上构建的微流体设备仍处于早期开发阶段(原型),需要在制造、分析技术和性能方面进行多项改进,以成为可以作为现实世界产品进行调整和商业化的成熟平台。然而,它们作为可穿戴设备具有很大的潜力。和性能成为成熟的平台,可以作为现实世界的产品进行调整和商业化。然而,它们作为可穿戴设备具有很大的潜力。和性能成为成熟的平台,可以作为现实世界的产品进行调整和商业化。然而,它们作为可穿戴设备具有很大的潜力。
更新日期:2017-07-14
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