Osteoarthritis of the knee (knee OA) is on the rise due to the aging population and increasing obesity. In addition to mechanical stress attributed to weight and age, osteoarthritis is associated with obesity and metabolic dysregulation. Here, a cross-sectional study targeting retrospectively registered 17,476 adults aged 50 years or older who were enrolled in the National Health and Nutrition Survey (2010–2011) was performed to analyze the association between the newly named metabolic associated fatty liver disease (MAFLD) and knee OA. Fatty liver index (FLI) ≥ 60 confirmed the presence of MAFLD, and FLI < 30 indicated the absence of MAFLD. Knee OA was diagnosed according to the Kellgren–Lawrence scale based on knee radiography results. A complex sample logistic regression analysis was performed. Statistically significant factors were adjusted to estimate probability ratios, and 95% confidence intervals were used to investigate the association between knee OA and MAFLD. The probability of knee OA was 1.479 times higher in the presence of MAFLD than that in the normal group. The results indicate that MAFLD is significantly associated with knee OA, suggesting that these two disorders should be managed simultaneously.

由于人口老龄化和肥胖增加，膝骨关节炎（膝关节 OA）正在上升。除了归因于体重和年龄的机械应力外，骨关节炎还与肥胖和代谢失调有关。在这里，一项横断面研究以回顾性登记的 17,476 名年龄在 50 岁或以上的成年人为对象，这些人参加了国家健康和营养调查（2010-2011 年），以分析新命名的代谢相关脂肪肝病 (MAFLD) 与疾病之间的关联。和膝盖骨关节炎。脂肪肝指数（FLI）≥60证实存在MAFLD，FLI<30表明不存在MAFLD。根据膝关节 X 线照相结果，根据 Kellgren-Lawrence 量表诊断膝关节 OA。进行了复杂样本逻辑回归分析。调整具有统计学意义的因素以估计概率比，并使用 95% 置信区间来研究膝关节 OA 和 MAFLD 之间的关联。MAFLD存在时膝关节OA的概率是正常组的1.479倍。结果表明，MAFLD 与膝关节 OA 显着相关，这表明应同时管理这两种疾病。