NR1H4 rs35724 G>C variant modulates liver damage in nonalcoholic fatty liver disease,Liver International

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NR1H4 rs35724 G>C variant modulates liver damage in nonalcoholic fatty liver disease
Liver International ( IF 6.0 ) Pub Date : 2021-07-16 , DOI: 10.1111/liv.15016
Stefania Grimaudo ₁ , Paola Dongiovanni ₂ , Jussi Pihlajamäki ₃ , Mohammed Eslam ₄ , Hannele Yki-Järvinen ₅ , Rosaria Maria Pipitone ₁ , Guido Baselli ₆ , Calogero Cammà ₁ , Vito Di Marco ₁ , Marco Enea ₁ , Miriam Longo _{2,

7} , Grazia Pennisi ₁ , Daniele Prati ₈ , Rossella Zito ₁ , Anna Ludovica Fracanzani _{2,

6} , Antonio Craxì ₁ , Jacob George ₄ , Stefano Romeo ₉ , Luca Valenti _{6,

10} , Salvatore Petta ₁

Affiliation

Sezione di Gastroenterologia e Epatologia, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.
General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.
Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Department of Pathophysiology and Transplantation, Section Internal Medicine, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, Università degli Studi, Milano, Italy.
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.
Precision Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Cà Granda Pad Marangoni, Milan, Italy.
Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Pathophysiology and Transplantion, Università degli Studi, Milan, Italy.

Farnesoid X receptor (FXR) plays a key role in bile acid and lipid homeostasis. Experimental evidence suggests that it can modulate liver damage related to nonalcoholic fatty liver disease (NAFLD). We examined the impact of the NR1H4 rs35724 G>C, encoding for FXR, on liver damage in a large cohort of patients at risk of steatohepatitis.

中文翻译：

NR1H4 rs35724 G>C 变异调节非酒精性脂肪肝的肝损伤

法尼醇 X 受体 (FXR) 在胆汁酸和脂质稳态中起关键作用。实验证据表明，它可以调节与非酒精性脂肪性肝病 (NAFLD) 相关的肝损伤。我们检查了编码 FXR 的NR1H4 rs35724 G>C 对一大群有脂肪性肝炎风险的患者的肝损伤的影响。

更新日期：2021-07-16

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