We previously reported that the dorsal raphe nucleus (DRN) was involved in the regulation of maternal care in lactating female mice. The DRN receives multiple innervations from a variety of the brain regions. Corticotropin-releasing factor (CRF) Type 1 and Type 2 receptors are distributed in the DRN. Both receptors have been implicated in regulating negative aspects including stress, fear, and anxiety. However, it remains unknown how CRF receptors in the DRN regulate maternal care. In the present study, we investigated how CRF receptors in the DRN is involved in regulating maternal care in lactating female mice. Injection of antalarmin or antisauvagine-30, which is an antagonist of CRF Type 1 or Type 2 receptor, respectively, into the DRN increased the latency to retrieving pups into the nest and to crouching over pups, and decreased the duration of crouching over pups, indicating that blockage of CRF receptor signaling in the DRN decreased maternal care. Each treatment did not affect anxiety-related behaviors, which were assayed using the hole-board test. These results suggest that CRF receptor signaling in the DRN positively regulates maternal care in lactating female mice. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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小鼠中缝背核中促肾上腺皮质激素释放因子受体对母体护理的调节。

我们之前报道过中缝背核 (DRN) 参与了哺乳期雌性小鼠母体护理的调节。DRN 接收来自不同大脑区域的多重神经支配。促肾上腺皮质激素释放因子 (CRF) 1 型和 2 型受体分布在 DRN 中。这两种受体都与调节负面因素有关，包括压力、恐惧和焦虑。然而，DRN 中的 CRF 受体如何调节母体护理仍然未知。在本研究中，我们调查了 DRN 中的 CRF 受体如何参与调节哺乳期雌性小鼠的母体护理。将 antalarmin 或 antisauvagine-30（分别是 CRF 1 型或 2 型受体的拮抗剂）注射到 DRN 中会增加将幼崽收回巢穴和蹲伏在幼崽上方的潜伏期，并减少蹲伏在幼崽身上的持续时间，表明 DRN 中 CRF 受体信号传导的阻断降低了母体护理。每种治疗都不会影响焦虑相关行为，这些行为是使用孔板测试进行分析的。这些结果表明 DRN 中的 CRF 受体信号正调节哺乳期雌性小鼠的母体护理。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。