Central CO₂ chemoreception (CCR), a major chemical drive for breathing, can be quantified with a CO₂ re-breathing test to measure the hypercapnic ventilatory response (HCVR). An attenuated HCVR correlates with the severity of respiratory dysfunction after generalized convulsive seizures and is a potential biomarker for sudden unexpected death in epilepsy (SUDEP) risk. Vagus nerve stimulation (VNS) may reduce SUDEP risk, but for unclear reasons the risk remains higher during the first 2 years after implantation. The vagus nerve has widespread connections in the brainstem, including key areas related to CCR. Here we examined whether chronic electrical stimulation of the vagus nerve induces changes in CCR.

中文翻译：

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VNS 治疗癫痫患者的高碳酸血症通气反应：病例对照研究

中枢CO _{2化学感受(CCR) 是呼吸的主要化学驱动力，可以通过CO 2}再呼吸测试来量化，以测量高碳酸血症通气反应(HCVR)。HCVR 减弱与全身性惊厥发作后呼吸功能障碍的严重程度相关，并且是癫痫猝死 (SUDEP) 风险的潜在生物标志物。迷走神经刺激 (VNS) 可能会降低 SUDEP 风险，但由于不明原因，在植入后的头 2 年内风险仍然较高。迷走神经在脑干中具有广泛的连接，包括与 CCR 相关的关键区域。在这里，我们检查了迷走神经的慢性电刺激是否会引起 CCR 的变化。