All around the world, non-engineered masonry constructions (NECs) typically have high vulnerability to seismic ground motion, resulting in heavy damage and severe casualties after earthquakes. Even though a number of computational strategies have been developed for seismic analysis of unreinforced masonry structures, a few studies have focussed on NECs located in developing countries. In this paper, different modelling options for finite element analysis of non-engineered masonry buildings are investigated. The goal of the study was to identify the modelling option with the best trade-off between computational burden and accuracy of results, in view of seismic risk assessment of NECs at regional scale. Based on the experimental behaviour of a single-storey structure representative of Indian non-engineered masonry buildings, the output of seismic response analysis of refined 3D models in ANSYS was compared to that of a simplified model based on 2D, nonlinear, layered shell elements in SAP2000. The numerical-experimental comparison was carried out under incremental static lateral loading, whereas nonlinear time history analysis was performed to investigate the dynamic performance of the case-study structure. Analysis results show that the simplified model can be a computationally efficient modelling option for both nonlinear static and dynamic analyses, particularly in case of force-based approaches for design and assessment of base isolation systems aimed at the large-scale seismic vulnerability mitigation of NECs.