Micro-reservoir based drug delivery systems have the potential to provide targeted drug release locally in the intestine, i.e. at the inflamed areas of the intestine of patients with inflammatory bowel disease (IBD). In this study, microcontainers with a diameter of 300 µm and a height of 100 µm, asymmetrical geometry and the possibility to provide unidirectional release, are fabricated in the biodegradable polymer poly-ɛ-caprolactone (PCL) using hot punching. As a first step towards local treatment of IBD, a novel method for loading of microcontainers with the corticosteroid budesonide is developed. For this purpose, a budesonide-Soluplus drug-polymer film is prepared by spin coating and loaded into the microcontainer reservoirs using hot punching. The processing parameters are optimized to achieve a complete loading of a large number of containers in a single step. A poly(lactic-co-glycolic acid) (PLGA) 50:50 lid is subsequently applied by spray coating. Solid-state characterization indicates that the drug is in an amorphous state in the drug-polymer films and the in vitro drug release profile showed a 68% release over 10 h. The results demonstrate that hot punching can be employed both as a production and loading method for PCL microcontainers with the perspective of local treatment of IBD.

基于微储库的药物递送系统有可能在肠道局部提供靶向药物释放，即在炎症性肠病 (IBD) 患者肠道的发炎区域。在这项研究中，使用热冲压在生物可降解聚合物聚-ɛ-己内酯 (PCL) 中制造了直径为 300 µm、高度为 100 µm、不对称几何形状和提供单向释放的可能性的微型容器。作为局部治疗 IBD 的第一步，开发了一种用皮质类固醇布地奈德装载微容器的新方法。为此，通过旋涂制备布地奈德-Soluplus 药物-聚合物薄膜，并使用热冲压将其装入微容器储库中。优化处理参数以在单个步骤中实现大量容器的完整装载。随后通过喷涂施加聚（乳酸-乙醇酸共聚物）（PLGA）50:50 的盖子。固态表征表明药物在药物聚合物薄膜中处于无定形状态，并且体外药物释放曲线显示在 10 小时内释放 68%。结果表明，从局部治疗 IBD 的角度来看，热冲压可以用作 PCL 微型容器的生产和装载方法。