Background: The genus Morus is one of the rich sources of phytomedicine and considered a beneficial natural source for drugs with potential antimicrobial effect under the traditional system of medicine.

Introduction: In the present study, three bioactive compounds isolated from the leaves of two species of genus Morus and their antibacterial effect against selective pathogens were assessed.

Methods: The inhibitory effects of the three molecules isolated were assessed for their minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) against selected pathogens. The in-silico studies provided the toxicity profile and the binding interactions with glucosamine- 6-phosphate synthase for all the isolates.

Results: Among the three compounds tested, cathafuran-B showed a prominent bacteriostatic and bactericidal effect, which is supported by the results of in-silico analysis suggesting that cathafuran- B could be a potential glucosamine-6-phosphate synthase inhibitor.

Conclusion: The biomolecule isolated from less explored Morus laevigata exhibiting higher antibacterial effect among the compounds tested warranted opening a new prospect in phytomedicinal research for exploring its pharmacological properties and lowering the utilization load present on highly explored Morus alba.

背景：桑属是植物药的丰富来源之一，被认为是传统医学体系下具有潜在抗菌作用的药物的有益天然来源。

介绍：在本研究中，评估了从两种桑属植物的叶子中分离的三种生物活性化合物及其对选择性病原体的抗菌作用。

方法：评估分离的三种分子对选定病原体的最小抑制浓度 (MIC) 和最小杀菌浓度 (MBC) 的抑制作用。计算机内研究提供了所有分离株的毒性特征和与葡糖胺-6-磷酸合酶的结合相互作用。

结果：在测试的三种化合物中，cathafuran-B 显示出显着的抑菌和杀菌作用，这得到了计算机分析结果的支持，表明 cathafuran-B 可能是一种潜在的 6-磷酸葡萄糖胺合酶抑制剂。

结论：从较少探索的桑树中分离出的生物分子在测试的化合物中表现出更高的抗菌作用，为探索其药理特性和降低高度探索的桑树的利用负荷开辟了植物医学研究的新前景。