We evaluated the relationship between daily stair climbing activity and vascular function as assessed by flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID). This study was a cross-sectional study. A total of 374 patients with hypertension were enrolled. The subjects were divided into three groups based on their daily stair climbing habit: no stairs group, climbing stairs to the 2nd-floor group, and climbing stairs to the ≥3rd-floor group. There was a significant difference in FMD between the ≥3rd-floor group and the other two groups (3.3 ± 2.5% vs. 2.3 ± 2.7% and 2.4 ± 2.7%, p = 0.02, respectively). FMD values were similar in the no stairs group and the 2nd-floor group (p = 0.96). There was a significant difference in NID between the no stairs group and the other two groups (7.4 ± 4.2% vs. 10.9 ± 5.3% and 11.3 ± 5.1%, p < 0.001, respectively). NID values were similar in the second-floor group and the ≥3rd-floor group (p = 0.86). These findings suggest that both endothelial function and vascular smooth muscle function are impaired in individuals who do not climb stairs and that endothelial function but not vascular smooth muscle function is impaired in individuals who climb stairs to the second floor compared with individuals who climb stairs to the ≥3rd floor. Stair climbing activity, a simple method for assessing daily physical activity, may reflect vascular function in patients with hypertension.

我们通过流动介导的血管舒张 (FMD) 和硝酸甘油诱导的血管舒张 (NID) 评估了日常爬楼梯活动与血管功能之间的关系。本研究为横断面研究。共招募了 374 名高血压患者。将受试者根据日常爬楼梯的习惯分为三组：不爬楼梯组、爬楼梯到2楼组、爬楼梯到≥3楼组。≥3 楼组与其他两组之间的 FMD 存在显着差异（分别为 3.3 ± 2.5% vs. 2.3 ± 2.7% 和 2.4 ± 2.7%，p  = 0.02）。无楼梯组和二楼组 FMD 值相似（p = 0.96)。无楼梯组与其他两组的 NID 存在显着差异（分别为 7.4 ± 4.2% 和 10.9 ± 5.3% 和 11.3 ± 5.1%，p  < 0.001）。二楼组和≥三楼组的 NID 值相似（p  = 0.86）。这些发现表明，不爬楼梯的人内皮功能和血管平滑肌功能均受损，与爬楼梯到二楼的人相比，爬楼梯到二楼的人内皮功能受损，但血管平滑肌功能不受损。 ≥3楼。爬楼梯活动是一种评估日常体力活动的简单方法，可反映高血压患者的血管功能。