Since the 1970s, glyphosate has become the most used herbicide of the world. The general population is ubiquitously exposed to glyphosate. Its long-term toxicity, carcinogenic potential and other health effects are controversially discussed. Even though the possible health impacts of glyphosate are of global concern, no population-wide monitoring of glyphosate was done yet. This study presents the worldwide first population-representative data on glyphosate and its metabolite aminomethylphosphonic acid (AMPA) for children and adolescents. 2144 first-morning void urine samples of 3–17-year-old children and adolescents living in Germany were analysed for concentrations of glyphosate and AMPA in the German Environmental Survey for Children and Adolescents 2014–2017 (GerES V). In 52 % of the samples (46 % for AMPA) the urinary glyphosate concentrations were above the limit of quantification of 0.1 µg/L. The geometric mean concentrations were 0.107 µg/L (0.090 µg/g_creatinine) for glyphosate and 0.100 µg/L (0.085 µg/g_creatinine) for AMPA. No clear association between exposure to glyphosate or AMPA and vegetarian diet or consumption of cereals, pulses, or vegetables could be identified. The low quantification rate and the 95th percentiles for glyphosate and AMPA of around 0.5 µg/L demonstrate an overall low exposure of the young population in Germany.

自 20 世纪 70 年代以来，草甘膦已成为世界上使用最多的除草剂。一般人群普遍接触草甘膦。其长期毒性、潜在致癌性和其他健康影响存在争议。尽管草甘膦可能对健康造成的影响受到全球关注，但尚未对草甘膦进行全民监测。这项研究提出了全球首个关于儿童和青少年草甘膦及其代谢物氨甲基膦酸 (AMPA) 的人群代表性数据。 2014-2017 年德国儿童和青少年环境调查 (GerES V) 对居住在德国的 3-17 岁儿童和青少年的 2144 份第一天早上的尿液样本进行了草甘膦和 AMPA 浓度分析。 52% 的样品（AMPA 为 46%）中尿草甘膦浓度高于 0.1 µg/L 的定量限。草甘膦的几何平均浓度为 0.107 µg/L（0.090 µg/g_肌酐），AMPA 的几何平均浓度为 0.100 µg/L（0.085 µg/g_肌酐）。尚未发现接触草甘膦或 AMPA 与素食或食用谷物、豆类或蔬菜之间存在明确关联。草甘膦和 AMPA 的低定量率和第 95 个百分位数约为 0.5 µg/L，表明德国年轻人口的总体暴露水平较低。