In order to deal with the challenge of biofilms and its associated infections, it is important to develop some efficient methodology which prevents the formation of biofilms over the surfaces. Herein, we have successfully developed an antibacterial and antibiofilm composite using non-toxic and hydrophobic nanomaterial, graphene nanoplatelets, via facile two step methodology including functionalization and subsequent hydrothermal treatment. The as-prepared composites were characterized using FE-SEM, FTIR and Raman spectroscopy to obtain morphological, compositional and structural details. In addition, the antibacterial efficiency of these composites was investigated against antibiotic resistant S. aureus and E. coli. Afterwards, graphene composite based epoxy coatings were prepared on glass substrate and tested for their antibiofilm efficiency against methicillin resistant S. aureus strain. The abundant presence of hydroxyl groups over the surface due to tannic acid, hydrophobicity of graphene and epoxy and remarkable antibacterial efficiency of tannic acid (TA), silver (Ag) and graphene synergistically enhance the antibiofilm efficiency of such coatings. This work presents a new strategy to develop a multifunctional coating and subsequently lessen the risk of biofilm assisted infections.

为了应对生物膜及其相关感染的挑战，重要的是开发一些有效的方法来防止在表面形成生物膜。在此，我们通过简单的两步方法，包括功能化和随后的水热处理，使用无毒和疏水的纳米材料石墨烯纳米片成功开发了一种抗菌和抗生物膜复合材料。使用 FE-SEM、FTIR 和拉曼光谱对制备的复合材料进行表征，以获得形态、成分和结构细节。此外，研究了这些复合材料对抗生素耐药性金黄色葡萄球菌和大肠杆菌的抗菌效率. 然后，在玻璃基板上制备基于石墨烯复合材料的环氧涂层，并测试其对耐甲氧西林金黄色葡萄球菌菌株的抗生物膜效率。由于单宁酸、石墨烯和环氧树脂的疏水性以及单宁酸 (TA)、银 (Ag) 和石墨烯的显着抗菌效率，表面上大量存在的羟基协同提高了此类涂层的抗生物膜效率。这项工作提出了一种开发多功能涂层并随后降低生物膜辅助感染风险的新策略。