There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to fight infection and one of these immune functions is phagocytosis. Effective and timely phagocytosis of parasites, accompanied by the activation of a regulated inflammatory response, is beneficial for parasite clearance. Functional studies have identified specific opsonins, particularly antibodies and distinct phagocyte sub-populations that are associated with clinical protection against malaria. In addition, cellular and molecular studies have enhanced the understanding of the immunological pathways and outcomes following phagocytosis of malaria parasites. In this review, an integrated view of the factors that can affect phagocytosis of infected erythrocytes and parasite components, the immunological consequences and their association with clinical protection against Plasmodium spp. infection is provided. Several red blood cell disorders and co-infections, and drugs that can influence phagocytic capability during malaria are also discussed. It is hoped that an enhanced understanding of this immunological process can benefit the design of new therapeutics and vaccines to combat this infectious disease.

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影响疟疾寄生虫吞噬作用的因素：迄今为止的故事

已知的疟原虫有七种。可以感染人类。人类宿主可以建立一个复杂的免疫反应网络来对抗感染，其中一种免疫功能是吞噬作用。有效和及时的寄生虫吞噬作用，伴随着受调节的炎症反应的激活，有利于寄生虫的清除。功能研究已经确定了特定的调理素，特别是抗体和不同的吞噬细胞亚群，它们与疟疾的临床保护有关。此外，细胞和分子研究增强了对疟原虫吞噬作用后免疫途径和结果的理解。在这篇综述中，综合分析了影响感染红细胞和寄生虫成分吞噬作用的因素，免疫学后果及其与对疟原虫的临床保护的关联。提供感染。还讨论了几种红细胞疾病和合并感染，以及可能影响疟疾期间吞噬能力的药物。希望对这种免疫过程的深入了解有助于设计新的疗法和疫苗来对抗这种传染病。