A nanoprobe based on polydopamine-coated gold nanobipyramids surface modified with molecules of a phenylboronic acid-substituted distyryl boron dipyrromethene has been fabricated and characterised using various physical and spectroscopic methods. It serves as an ultrasensitive sensor for sialic acids on the surface of cancer cells based on its dual surface-enhanced Raman scattering and fluorescence response. This biomarker can also trigger the photodynamic activity of these nanobipyramids, effectively eradicating the cancer cells mainly through apoptosis as shown by various bioassays.

中文翻译：

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使用染料修饰的聚多巴胺涂层金纳米双锥体检测细胞表面唾液酸和光动力根除癌细胞

基于聚多巴胺涂层的金纳米双锥体表面用苯基硼酸取代的二苯乙烯基硼二吡咯亚甲基修饰的纳米探针已经制造并使用各种物理和光谱方法进行了表征。基于其双重表面增强拉曼散射和荧光响应，它可用作癌细胞表面唾液酸的超灵敏传感器。这种生物标志物还可以触发这些纳米双锥体的光动力活性，如各种生物测定所示，主要通过细胞凋亡有效地消灭癌细胞。