Background Although several studies have reported an association between atherosclerosis-related diseases and COVID-19, the relationship between COVID-19 severity and atherosclerosis progression remains unclear. The aim of this study is to determine the coronary artery calcium score (CACS) prognostic value in patients with COVID-19 using indices such as deterioration in oxygenation and CT images of the chest. Methods This was a single-centre retrospective study of 53 consecutive patients with COVID-19 in Narita who were admitted to our hospital between March 2020 and August 2020. CACS was calculated based on non-gated CT scans of the chest performed on admission day. The patients were divided into the following two groups based on CACS: group 1 (CACS ≥180, n=11) and group 2 (CACS <180, n=42). Following univariate analysis of the main variables, multivariate analysis of variables that may be associated with COVID-19 progression was performed. Results Multivariable logistic regression analysis of age, sex, smoking history, diabetes, hypertension, dyslipidaemia, number of days from symptom onset to hospitalisation and CACS of ≥180 was performed. It revealed that unlike CACS of <180, CACS of ≥180 is associated with exacerbation of oxygenation or CT images of the chest during hospitalisation (OR: 12.879, 95% CI: 1.399 to 380.401). Furthermore, this model of eight variables showed good calibration (Hosmer-Lemeshow p=0.119). Conclusion CACS may be a prognosis marker of COVID-19 severity. Although coronary artery calcification is not typically assessed in pneumonia cases, it may provide a valuable clinical indicator for predicting severe COVID-19 outcomes. Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information. All data relevant to the study are included in the article or uploaded as supplementary information. Data are available upon reasonable request.

中文翻译：

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冠状动脉钙化评分可能是 COVID-19 预后的新预测指标：一项回顾性研究

背景 尽管多项研究报告了动脉粥样硬化相关疾病与 COVID-19 之间的关联，但 COVID-19 严重程度与动脉粥样硬化进展之间的关系仍不清楚。本研究的目的是使用氧合恶化和胸部 CT 图像等指标来确定 COVID-19 患者的冠状动脉钙化评分 (CACS) 预后价值。方法 这是一项单中心回顾性研究，对成田市 2020 年 3 月至 2020 年 8 月期间入院的 53 名连续 COVID-19 患者进行了单中心回顾性研究。 CACS 是根据入院当天进行的胸部非门控 CT 扫描计算得出的。根据CACS将患者分为以下两组：第1组（CACS≥180，n=11）和第2组（CACS<180，n=42）。在对主要变量进行单变量分析后，对可能与 COVID-19 进展相关的变量进行了多变量分析。结果 对年龄、性别、吸烟史、糖尿病、高血压、血脂异常、发病至住院天数、CACS≥180天数进行多变量logistic回归分析。结果表明，与 <180 的 CACS 不同，≥180 的 CACS 与住院期间氧合恶化或胸部 CT 图像有关（OR：12.879，95% CI：1.399 至 380.401）。此外，该八个变量的模型显示出良好的校准（Hosmer-Lemeshow p=0.119）。结论 CACS 可能是 COVID-19 严重程度的预后标志物。尽管冠状动脉钙化通常不会在肺炎病例中进行评估，但它可能为预测严重的 COVID-19 结果提供有价值的临床指标。可应合理要求提供数据。与研究相关的所有数据都包含在文章中或作为补充信息上传。与研究相关的所有数据都包含在文章中或作为补充信息上传。可应合理要求提供数据。