Olanexidine gluconate 1.5% (Olanedine^®) is a colorless and transparent antiseptic agent introduced in 2015. In this study, we examined its usefulness and safety for cardiovascular catheterization and compared them to 10% povidone-iodine (PI). The study included 1,001 and 1,000 consecutively enrolled patients using Olanedine^® and PI, respectively [649 (PI, 687) males; mean age: 72.1 ± 9.6 (70.9 ± 9.6) years] who underwent cardiovascular catheterization [diagnostic cardiac catheterization: 624 (509) cases, percutaneous coronary intervention: 288 (390) cases, and endovascular treatment: 89 (101) cases]. Clinically, there were no significant differences in the backgrounds between the two groups. The amount of Olanedine^® used per case was approximately 20 mL. Blood tests were performed before and after catheterization. The presence or absence of discoloration on clothes containing cotton by Olanedine^® was also examined. One mild rash that disappeared within one day occurred in each of the two groups. Some blood tests before and after cardiac catheterization indicated significant differences, but they did not seem to be clinically relevant. The use of Olanedine^® in hemodialysis patients (117 cases) was uneventful. Its use in 37 patients with contraindications for ethanol disinfection was also uneventful. Although PI is extremely difficult to remove from white coats containing cotton, Olanedine^® did not cause any discoloration on clothes. This is the first report of cardiovascular catheterization using Olanedine^®. The efficacy and safety of Olanedine^® and PI seem to be equivalent. Olanedine^® could be a new useful option as a disinfectant of cardiovascular catheterization.

葡萄糖酸奥兰西定 1.5% (Olanedine ^® ) 是 2015 年推出的无色透明防腐剂。在本研究中，我们检查了其在心血管导管插入术中的实用性和安全性，并将其与 10% 聚维酮碘 (PI) 进行了比较。该研究分别包括 1,001 和 1,000 名使用 Olanedine ^®和 PI连续入组的患者[649 (PI, 687) 男性；平均年龄：72.1±9.6（70.9±9.6）岁]接受心血管导管插入术[诊断性心导管术：624（509）例，经皮冠状动脉介入术：288（390）例​​，血管内治疗：89（101）例]。在临床上，两组之间的背景没有显着差异。Olanedine ^®的用量每例使用约 20 mL。在导管插入术之前和之后进行血液检查。还检查了 Olanedine ^®对含棉衣服是否变色。两组中的每一组都发生了一个在一天内消失的轻度皮疹。心脏导管插入术前后的一些血液检查表明存在显着差异，但它们似乎没有临床相关性。在血液透析患者（117 例）中使用 Olanedine ^®是平安无事的。它在 37 名有乙醇消毒禁忌症的患者中的使用也平安无事。尽管 PI 极难从含棉的白色涂层中去除，但 Olanedine ^®不会对衣服造成任何变色。这是使用 Olanedine ^®进行心血管导管插入术的第一份报告。Olanedine ^®和PI的疗效和安全性似乎相当。Olanedine ^®作为心血管导管插入术的消毒剂可能是一种新的有用选择。