Heart rate modulation therapy using ivabradine improves mortality and morbidity in patients with systolic dysfunction. However, a target heart rate remains uncertain. Echocardiography-guided ivabradine therapy, in which we attempt to approach zero overlap between two diastolic filling inflow waves, has recently been proposed to maximize cardiac output, facilitate reverse remodeling, and reduce mortality and morbidity, instead of using an absolute value for the target heart rate. Prospective studies are needed to validate the clinical implication of these therapeutic strategies. Also, this concept should be expanded to other clinical scenarios.

中文翻译：

---

使用伊伐布雷定的最佳心率调节

使用伊伐布雷定的心率调节疗法可改善收缩功能障碍患者的死亡率和发病率。然而，目标心率仍然不确定。超声心动图引导的伊伐布雷定治疗，我们试图在两个舒张期充盈流入波之间接近零重叠，最近有人提出最大限度地提高心输出量，促进反向重构，并降低死亡率和发病率，而不是使用目标心脏的绝对值速度。需要前瞻性研究来验证这些治疗策略的临床意义。此外，这个概念应该扩展到其他临床场景。