Group 3 innate lymphoid cells (ILC3) are innate effector cells that have essential roles in lymphoid organogenesis and maintenance of tissue homeostasis under steady-state and pathogenic conditions. ILC3 also promote immune defense, notably during bacterial breach of epithelial barriers, including those caused by attaching and effacing (A/E) pathogens for which Citrobacter rodentium infection in mice is a relevant pre-clinical model. Through their ability to sustain interactions with tissue-resident immune cells, epithelial cells, neurons or stromal cells, ILC3 constitute a key orchestrator that maintains the intestinal barrier. In this review, we will examine the function of murine ILC3 in host defense against C. rodentium infection and provide a discussion of recent advances that help elucidate the specific roles of these novel innate immune effector cells at mucosal surfaces.

第 3 组先天淋巴细胞 (ILC3) 是先天效应细胞，在稳态和致病条件下，在淋巴器官发生和维持组织稳态中具有重要作用。ILC3 还促进免疫防御，特别是在细菌破坏上皮屏障期间，包括由附着和消除 (A/E) 病原体引起的免疫防御，小鼠柠檬酸杆菌感染是相关的临床前模型。通过维持与组织驻留免疫细胞、上皮细胞、神经元或基质细胞相互作用的能力，ILC3 构成了维持肠道屏障的关键协调者。在这次审查中，我们将研究小鼠ILC3的对抗宿主防御功能啮齿柠檬酸杆菌 感染并讨论最近的进展，这些进展有助于阐明这些新型先天免疫效应细胞在粘膜表面的具体作用。