Amphiphilic Histidine-Based Oligopeptides Exhibit pH-Reversible Fibril Formation,ACS Macro Letters

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Amphiphilic Histidine-Based Oligopeptides Exhibit pH-Reversible Fibril Formation
ACS Macro Letters ( IF 5.1 ) Pub Date : 2021-07-15 , DOI: 10.1021/acsmacrolett.1c00142
Carlos Noble Jesus _{1,

2} , Rhys Evans ₁ , Joe Forth _{1,

2} , Carolina Estarellas ₁ , Francesco Luigi Gervasio _{1,

3} , Giuseppe Battaglia _{1,

2,

4,

5}

Affiliation

We report the design, simulation, synthesis, and reversible self-assembly of nanofibrils using polyhistidine-based oligopeptides. The inclusion of aromatic amino acids in the histidine block produces distinct antiparallel β-strands that lead to the formation of amyloid-like fibrils. The structures undergo self-assembly in response to a change in pH. This creates the potential to produce well-defined fibrils for biotechnological and biomedical applications that are pH-responsive in a physiologically relevant range.

中文翻译：

基于两亲性组氨酸的寡肽表现出 pH 可逆的原纤维形成

我们报告了使用基于多组氨酸的寡肽的纳米纤维的设计、模拟、合成和可逆自组装。组氨酸块中包含芳香族氨基酸会产生不同的反平行 β 链，从而导致淀粉样蛋白样原纤维的形成。这些结构会随着 pH 值的变化而进行自组装。这创造了为生物技术和生物医学应用生产定义明确的原纤维的潜力，这些原纤维在生理相关范围内具有 pH 响应性。

更新日期：2021-08-17

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