Effective and ecofriendly converting biomass to chemicals is important for sustainable engineering based on the foreseeable shortage of fossil resources. Undecylprodigiosin (UP) is a promising antibiotic, but the direct feeding of pure precursor amino acids makes it costly for large-scale production. Here, collagen peptide (CP), a renewable animal-derived biomass contains abundant precursor amino acids of UP. CP can act as carbon and nitrogen source for the growth of Streptomyces coelicolor CGMCC 4.7172. The plant biomasses including soybean meal, wheat bran, and malt extract were unsuitable for UP prodution. However, 365.40 µg/L UP was detected after 24 h in the media containing CP, and its highest concentration reached 1198.01 µg/L. UP was also detected in the media containing meat hydrolysates of domestic animals, but its initial production time was delayed, and final concentration was lower than that in the medium containing CP only. Compared the fermentation performances of CP and other proteins, CP has a special superiority for UP production. These results revealed that UP biosynthesis may be dependent on amino acid availability of substrates and CP is beneficial for UP production because of its specific amino acid composition.

中文翻译：

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胶原蛋白肽为天蓝色链霉菌CGMCC 4.7172 提供丰富的前体，以增强十一烷基灵菌红素的产生

基于可预见的化石资源短缺，有效且环保地将生物质转化为化学品对于可持续工程非常重要。十一烷基灵菌红素 (UP) 是一种很有前途的抗生素，但直接添加纯前体氨基酸使其大规模生产成本高昂。在这里，胶原蛋白肽 (CP)，一种可再生的动物源性生物质，含有丰富的 UP 前体氨基酸。CP 可以作为天蓝色链霉菌 CGMCC 4.7172 生长的碳源和氮源。包括豆粕、麦麸和麦芽提取物在内的植物生物质不适合 UP 生产。然而，在含有 CP 的培养基中，24 小时后检测到 365.40 µg/L UP，其最高浓度达到 1198.01 µg/L。在含有家畜肉水解物的培养基中也检测到 UP，但其初始生产时间延迟，最终浓度低于仅含CP的培养基。CP与其他蛋白质的发酵性能相比，CP在UP生产中具有特殊的优势。这些结果表明，UP 生物合成可能取决于底物的氨基酸可用性，而 CP 由于其特定的氨基酸组成而有利于 UP 生产。