Inflammation is an essential mechanism of various diseases. The development and resolution of inflammation are complex immune-modulation processes which induce the involvement of various types of immune cells. Specialized pro-resolving lipid mediators (SPMs) have been demonstrated to be signaling molecules in inflammation. SPMs are involved in the pathophysiology of different diseases, especially respiratory diseases, including asthma, pneumonia, and chronic obstructive pulmonary disease. All of these diseases are related to the inflammatory response and its persistence. Therefore, a deeper understanding of the mechanisms and development of inflammation in respiratory disease, and the roles of the SPM family in the resolution process, might be useful in the quest for novel therapies and preventive measures for pulmonary diseases.

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专门的促分解脂质介质在肺部炎症疾病中的作用：机制和发展

炎症是各种疾病的重要机制。炎症的发展和消退是复杂的免疫调节过程，其诱导各种类型的免疫细胞参与。专门的促分解脂质介质 (SPM) 已被证明是炎症中的信号分子。SPM 参与不同疾病的病理生理学，尤其是呼吸系统疾病，包括哮喘、肺炎和慢性阻塞性肺病。所有这些疾病都与炎症反应及其持续存在有关。因此，更深入地了解呼吸系统疾病炎症的机制和发展，以及 SPM 家族在消退过程中的作用，可能有助于寻求肺部疾病的新疗法和预防措施。