The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) is an obesity-associated malignancy with increasing prevalence, dismal prognosis, and severely dysregulated immune processes. We previously reported that αβ T cells migrate to omentum and liver in OAC and contribute to inflammation in these tissues. Here, we assessed the tissue distribution and phenotype of gamma/delta (γδ) T cells in the blood, omentum, liver and tumour of OAC patients.

Our data show that the Vδ1 and Vδ3 subsets of γδ T cells are most prevalent in omentum and liver of OAC patients. Furthermore, γδ T cells are predominantly pro-inflammatory in these tissues, and co-express IFN-γ and IL-17. Moreover, γδ T cells exhibit cytotoxic capabilities in OAC omentum and liver.

This study provides the first indication that γδ T cells contribute to obesity-associated inflammation in OAC and might be exploited therapeutically.

全球肥胖症的流行正在导致由慢性炎症（包括癌症）引发的疾病的患病率增加。食管腺癌 (OAC) 是一种与肥胖相关的恶性肿瘤，其患病率不断增加，预后不佳，免疫过程严重失调。我们之前报道过，αβ T 细胞迁移到 OAC 中的网膜和肝脏，并导致这些组织的炎症。在这里，我们评估了 OAC 患者血液、网膜、肝脏和肿瘤中 γ/δ (γδ) T 细胞的组织分布和表型。

我们的数据显示，γδ T 细胞的 Vδ1 和 Vδ3 亚群在 OAC 患者的大网膜和肝脏中最为普遍。此外，γδ T 细胞在这些组织中主要是促炎的，并共同表达 IFN-γ 和 IL-17。此外，γδ T 细胞在 OAC 网膜和肝脏中表现出细胞毒性能力。

这项研究提供了第一个迹象，即 γδ T 细胞有助于 OAC 中与肥胖相关的炎症，并可能在治疗上加以利用。