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Antioxidant and antithrombotic effects of green mussels (Perna canaliculus) in rats
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-07-14 , DOI: 10.1111/jfbc.13865 Abdullah F Aldairi 1 , Reema A Alyamani 2 , Ayman Al-Hazmi 3 , Ibrahim F Halawani 3 , Asma A Alsubaihi 4 , Shaker Idris 1 , Nada A Fallatah 1 , Abdulaziz Gassas 2 , Abdulraheem A Almalki 3 , Ahmed Qasem 1 , Mazen M Ghaith 1 , Hussain Almasmoum 1 , Ahmad A Alghamdi 3 , Mamdouh Allahyani 3 , Riyad A Almaimani 4 , Hussain Banni 5 , Mashael Alkhanabashi 6
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-07-14 , DOI: 10.1111/jfbc.13865 Abdullah F Aldairi 1 , Reema A Alyamani 2 , Ayman Al-Hazmi 3 , Ibrahim F Halawani 3 , Asma A Alsubaihi 4 , Shaker Idris 1 , Nada A Fallatah 1 , Abdulaziz Gassas 2 , Abdulraheem A Almalki 3 , Ahmed Qasem 1 , Mazen M Ghaith 1 , Hussain Almasmoum 1 , Ahmad A Alghamdi 3 , Mamdouh Allahyani 3 , Riyad A Almaimani 4 , Hussain Banni 5 , Mashael Alkhanabashi 6
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In the past decade, the use of marine mussels as seafood is being more popular. They considered being a rich source of various nutritional bioactive compounds that aroused the scientific community's interest. This study investigated the antioxidant and the antithrombotic consequences on Sprague-Dawley male rats after adding dried New Zealand mussel Perna canaliculus in their diet. The biochemical, hematological and histopathological changes were also observed. Forty rats were divided into four groups according to the amount of dried mussels in their diet, in addition to a control group that consumed a basal diet only. Group 1 consumed 25% dried mussels in its basal diet; Group 2 consumed 35% dried mussels in its basal diet, and Group 3 was consumed 45% dried mussels in its basal diet. The biochemical parameters showed improvements in liver function. Interestingly, the lipid profile decreased, especially the low-density lipoprotein cholesterol (LDL-C) levels which were reduced significantly in Group 3 (p < .01). These observations were accompanied by a decrease in iron levels significantly as the amount of dried mussels increased (p < .01). Furthermore, the noticed changes in the hematological profile prove that there is an increase in antithrombotic activity. Dried mussels had potent antioxidant effects in the liver as shown by increased lipid peroxide (p < .05), reduced glutathione (p < .05), and glutathione peroxidase (GSH-Px; p < .05). Additionally, antioxidant activity in the kidney was shown to increase through GSH-Px activity (p < .01). In conclusion, these results indicate that consuming dried mussels resulted in improved biochemical and antioxidants activities and could be used as an antithrombotic agent.
中文翻译：
绿贻贝（Perna canaliculus）对大鼠的抗氧化和抗血栓形成作用
在过去的十年中，使用海贻贝作为海鲜越来越受欢迎。他们认为这是引起科学界兴趣的各种营养生物活性化合物的丰富来源。本研究调查了加入干燥的新西兰贻贝Perna canaliculus后对 Sprague-Dawley 雄性大鼠的抗氧化和抗血栓形成效果在他们的饮食中。还观察到生化、血液学和组织病理学的变化。除了仅食用基础饮食的对照组外，40 只大鼠根据其饮食中干贻贝的数量分为四组。第 1 组在其基础饮食中食用了 25% 的干贻贝；第 2 组在其基础饮食中消耗了 35% 的干贻贝，第 3 组在其基础饮食中消耗了 45% 的干贻贝。生化参数显示肝功能有所改善。有趣的是，血脂水平降低，尤其是低密度脂蛋白胆固醇 (LDL-C) 水平在第 3 组中显着降低 ( p < .01)。随着干贻贝数量的增加，这些观察结果伴随着铁含量的显着下降（p < .01)。此外，血液学特征的显着变化证明抗血栓形成活性增加。干贻贝在肝脏中具有强大的抗氧化作用，表现为脂质过氧化物增加 ( p < .05)、谷胱甘肽减少 ( p < .05) 和谷胱甘肽过氧化物酶 (GSH-Px；p < .05)。此外，肾脏中的抗氧化活性显示通过 GSH-Px 活性增加 ( p < .01)。总之，这些结果表明食用干贻贝可提高生化和抗氧化活性，并可用作抗血栓形成剂。
更新日期：2021-09-06
中文翻译：
绿贻贝（Perna canaliculus）对大鼠的抗氧化和抗血栓形成作用
在过去的十年中，使用海贻贝作为海鲜越来越受欢迎。他们认为这是引起科学界兴趣的各种营养生物活性化合物的丰富来源。本研究调查了加入干燥的新西兰贻贝Perna canaliculus后对 Sprague-Dawley 雄性大鼠的抗氧化和抗血栓形成效果在他们的饮食中。还观察到生化、血液学和组织病理学的变化。除了仅食用基础饮食的对照组外，40 只大鼠根据其饮食中干贻贝的数量分为四组。第 1 组在其基础饮食中食用了 25% 的干贻贝；第 2 组在其基础饮食中消耗了 35% 的干贻贝，第 3 组在其基础饮食中消耗了 45% 的干贻贝。生化参数显示肝功能有所改善。有趣的是，血脂水平降低，尤其是低密度脂蛋白胆固醇 (LDL-C) 水平在第 3 组中显着降低 ( p < .01)。随着干贻贝数量的增加，这些观察结果伴随着铁含量的显着下降（p < .01)。此外，血液学特征的显着变化证明抗血栓形成活性增加。干贻贝在肝脏中具有强大的抗氧化作用，表现为脂质过氧化物增加 ( p < .05)、谷胱甘肽减少 ( p < .05) 和谷胱甘肽过氧化物酶 (GSH-Px；p < .05)。此外，肾脏中的抗氧化活性显示通过 GSH-Px 活性增加 ( p < .01)。总之，这些结果表明食用干贻贝可提高生化和抗氧化活性，并可用作抗血栓形成剂。
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