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Fabrication and characterization of alginate/chitosan hydrogel combined with honey and aloe vera for wound dressing applications
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2021-07-15 , DOI: 10.1002/app.51398 Mostafa Saberian 1 , Ehsan Seyedjafari 2 , Seyed Jalal Zargar 3 , Fatemeh Sadat Mahdavi 2 , Parisa Sanaei‐rad 4
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2021-07-15 , DOI: 10.1002/app.51398 Mostafa Saberian 1 , Ehsan Seyedjafari 2 , Seyed Jalal Zargar 3 , Fatemeh Sadat Mahdavi 2 , Parisa Sanaei‐rad 4
Affiliation
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Hydrogels can be one of the best polymeric wound dressings due to the desirable properties of wound healing. In this study, emphasizing the use of natural biomaterials such as Aloe vera and honey in the structure of cross-linked polymers, a novel hydrogel was produced that might be applied to healing wounds. In the beginning, four hydrogel groups were made from a combination of Sodium Alginate and Chitosan with Aloe vera extract and honey in optimum concentrations. Then the structure of those was evaluated by SEM and FTIR. After confirming hydrogels' structural properties, their physical properties, including swelling, porosity, density, mass loss, stability, and WVTR, were examined. Besides, the hydrogel biocompatibility was assessed by analyzing the cell viability and hemolytic activity. Adhesion of the cells to the hydrogel was also observed by SEM imaging. The results showed that the designed hydrogel has a porous structure with interconnected cavities, which their size can provide suitable conditions for cell adhesion, migration, and proliferation. Also, their physical and structural properties can be a strong suit to wound healing. Although honey's application can weaken the hydrogel structure, honey has beneficial properties due to its complex biomolecules. In contrast, Aloe vera in hydrogel generally improved the hydrogel's specificity for wound healing. According to the results of this study, taking advantage of hydrogels containing honey and Aloe vera based on alginate and chitosan polymers led to the formation of an acceptable structure and biocompatibility that can be used in future researches to repair tissues, especially wounds.
中文翻译：
海藻酸盐/壳聚糖水凝胶结合蜂蜜和芦荟用于伤口敷料的制备和表征
由于伤口愈合的理想特性，水凝胶可以成为最好的聚合物伤口敷料之一。在这项研究中，强调在交联聚合物结构中使用芦荟和蜂蜜等天然生物材料，生产了一种可用于伤口愈合的新型水凝胶。最初，四个水凝胶组由海藻酸钠和壳聚糖与芦荟提取物和蜂蜜的组合制成在最佳浓度。然后通过SEM和FTIR评估它们的结构。在确认水凝胶的结构特性后，检查了它们的物理特性，包括膨胀、孔隙率、密度、质量损失、稳定性和 WVTR。此外，通过分析细胞活力和溶血活性来评估水凝胶的生物相容性。还通过 SEM 成像观察到细胞对水凝胶的粘附。结果表明，设计的水凝胶具有多孔结构和相互连接的空腔，其大小可以为细胞粘附、迁移和增殖提供合适的条件。此外，它们的物理和结构特性非常适合伤口愈合。虽然蜜'小号应用可以削弱水凝胶结构，由于其复杂的生物分子，蜂蜜具有有益的特性。相比之下，水凝胶中的芦荟通常提高了水凝胶对伤口愈合的特异性。根据这项研究的结果，利用基于海藻酸盐和壳聚糖聚合物的含有蜂蜜和芦荟的水凝胶形成了可接受的结构和生物相容性，可用于未来研究修复组织，尤其是伤口。
更新日期：2021-09-09
中文翻译：
海藻酸盐/壳聚糖水凝胶结合蜂蜜和芦荟用于伤口敷料的制备和表征
由于伤口愈合的理想特性，水凝胶可以成为最好的聚合物伤口敷料之一。在这项研究中，强调在交联聚合物结构中使用芦荟和蜂蜜等天然生物材料，生产了一种可用于伤口愈合的新型水凝胶。最初，四个水凝胶组由海藻酸钠和壳聚糖与芦荟提取物和蜂蜜的组合制成在最佳浓度。然后通过SEM和FTIR评估它们的结构。在确认水凝胶的结构特性后，检查了它们的物理特性，包括膨胀、孔隙率、密度、质量损失、稳定性和 WVTR。此外，通过分析细胞活力和溶血活性来评估水凝胶的生物相容性。还通过 SEM 成像观察到细胞对水凝胶的粘附。结果表明，设计的水凝胶具有多孔结构和相互连接的空腔，其大小可以为细胞粘附、迁移和增殖提供合适的条件。此外，它们的物理和结构特性非常适合伤口愈合。虽然蜜'小号应用可以削弱水凝胶结构，由于其复杂的生物分子，蜂蜜具有有益的特性。相比之下，水凝胶中的芦荟通常提高了水凝胶对伤口愈合的特异性。根据这项研究的结果，利用基于海藻酸盐和壳聚糖聚合物的含有蜂蜜和芦荟的水凝胶形成了可接受的结构和生物相容性，可用于未来研究修复组织，尤其是伤口。
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