We present two patients who presented with classical paraneoplastic syndromes with multiple central nervous system (CNS) autoantibodies in each case. The presence of multiple antibodies made the detection of a malignancy more likely and both patients were subsequently diagnosed with small cell lung carcinoma (SCLC). We highlight that the presence of multiple CNS autoantibodies increases the likelihood of detecting a malignancy but that the clinical presentation and response to treatment can vary despite similar antibody profiles. Clinicians should be alert to the need to search for occult malignancy in patients with multiple CNS autoantibodies.

我们介绍了两名患有经典副肿瘤综合征的患者，每例患者均具有多种中枢神经系统 (CNS) 自身抗体。多种抗体的存在使检测出恶性肿瘤的可能性更大，随后两名患者都被诊断出患有小细胞肺癌 (SCLC)。我们强调，多种 CNS 自身抗体的存在增加了检测恶性肿瘤的可能性，但尽管抗体谱相似，但临床表现和对治疗的反应可能会有所不同。临床医生应警惕在具有多种 CNS 自身抗体的患者中寻找隐匿性恶性肿瘤的必要性。