Lipid-Based Nanoparticles for Delivery of Vaccine Adjuvants and Antigens: Toward Multicomponent Vaccines,Molecular Pharmaceutics

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Lipid-Based Nanoparticles for Delivery of Vaccine Adjuvants and Antigens: Toward Multicomponent Vaccines
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2021-07-15 , DOI: 10.1021/acs.molpharmaceut.1c00447
Despo Chatzikleanthous _{1,

2} , Derek T O'Hagan ₃ , Roberto Adamo ₂

Affiliation

Despite the many advances that have occurred in the field of vaccine adjuvants, there are still unmet needs that may enable the development of vaccines suitable for more challenging pathogens (e.g., HIV and tuberculosis) and for cancer vaccines. Liposomes have already been shown to be highly effective as adjuvant/delivery systems due to their versatility and likely will find further uses in this space. The broad potential of lipid-based delivery systems is highlighted by the recent approval of COVID-19 vaccines comprising lipid nanoparticles with encapsulated mRNA. This review provides an overview of the different approaches that can be evaluated for the design of lipid-based vaccine adjuvant/delivery systems for protein, carbohydrate, and nucleic acid-based antigens and how these strategies might be combined to develop multicomponent vaccines.

中文翻译：

用于递送疫苗佐剂和抗原的基于脂质的纳米颗粒：迈向多组分疫苗

尽管在疫苗佐剂领域取得了许多进展，但仍有未满足的需求可能使开发适用于更具挑战性的病原体（例如 HIV 和结核病）和癌症疫苗的疫苗成为可能。由于其多功能性，脂质体已被证明作为佐剂/递送系统非常有效，并且可能会在该领域得到进一步的应用。最近批准的 COVID-19 疫苗突出了基于脂质的递送系统的广泛潜力，该疫苗包含带有封装 mRNA 的脂质纳米颗粒。本综述概述了可用于设计基于脂质的疫苗佐剂/蛋白质、碳水化合物和核酸抗原的递送系统的不同方法，以及如何结合这些策略来开发多组分疫苗。

更新日期：2021-08-03

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