Abstract

Benzimidazole and quinoline showed a large spectrum of activities in various pharmacological fields like anticonvulsant, antimicrobial, and antimalarial, including antiviral and anticancer also. The different pharmacologically active series gained the attention of many researchers, which resulted in different hybrid structure of benzimidazole and quinoline. These synthesized compounds showed positive results against different diseases. Quinoline and benzimidazole can either be fused or incorporated using either functional groups/bonds. Medicinal chemists predicted that these moieties could be interconnected to yield a novel or modified hybrid compound. This review summarized Benzimidazole – Quinoline hybrids with their biological activities.

摘要

苯并咪唑和喹啉在抗惊厥、抗菌和抗疟疾等各种药理领域显示出广泛的活性，包括抗病毒和抗癌。不同的药理活性系列引起了许多研究人员的关注，导致苯并咪唑和喹啉的杂化结构不同。这些合成的化合物对不同的疾病显示出积极的结果。喹啉和苯并咪唑可以使用任一官能团/键进行稠合或掺入。药物化学家预测，这些部分可以相互连接以产生一种新的或修饰的杂化化合物。本综述总结了苯并咪唑-喹啉杂化物及其生物活性。