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Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival
British Journal of Cancer ( IF 6.4 ) Pub Date : 2021-07-15 , DOI: 10.1038/s41416-021-01487-7
Emilie S Zoltick 1 , Stephanie A Smith-Warner 2, 3 , Chen Yuan 4 , Molin Wang 3, 5, 6 , Charles S Fuchs 7, 8 , Jeffrey A Meyerhardt 4 , Andrew T Chan 6, 9, 10, 11 , Kimmie Ng 4 , Shuji Ogino 3, 4, 10, 12 , Meir J Stampfer 2, 3, 6 , Edward L Giovannucci 2, 3, 6 , Kana Wu 2
Affiliation  

Background

The influence of a high sugar diet on colorectal cancer (CRC) survival is unclear.

Methods

Among 1463 stage I–III CRC patients from the Nurses’ Health Study and Health Professionals Follow-up Study, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC-specific and all-cause mortality in relation to intake of post-diagnosis sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB), fruit juice, fructose and other sugars.

Results

Over a median 8.0 years, 781 cases died (173 CRC-specific deaths). Multivariable-adjusted HRs for post-diagnosis intake and CRC-specific mortality were 1.21 (95% CI: 0.87–1.68) per 1 serving SSBs per day (serving/day) and 1.24 (95% CI: 0.95–1.63) per 20 grams fructose per day. Significant positive associations for CRC-specific mortality were primarily observed ≤5 years from diagnosis (HR per 1 serving/day of SSBs = 1.59, 95% CI: 1.06–2.38). Significant inverse associations were observed between ASBs and CRC-specific and all-cause mortality (HR for ≥5 versus <1 serving/week = 0.44, 95% CI: 0.26–0.75 and 0.70, 95% CI: 0.55–0.89, respectively).

Conclusions

Higher post-diagnosis intake of SSBs and sugars may be associated with higher CRC-specific mortality, but only up to 5 years from diagnosis, when more deaths were due to CRC. The inverse association between ASBs and CRC-specific mortality warrants further examination.



中文翻译:


含糖饮料、人工甜味剂饮料和糖摄入量与结直肠癌生存率


 背景


高糖饮食对结直肠癌(CRC)生存的影响尚不清楚。

 方法


在来自护士健康研究和健康专业人员随访研究的 1463 名 I-III 期 CRC 患者中,我们估计了 CRC 特异性死亡率和全因死亡率与摄入量相关的风险比 (HR) 和 95% 置信区间 (CI)诊断后含糖饮料(SSB)、人工甜味饮料(ASB)、果汁、果糖和其他糖。

 结果


中位 8.0 年期间,有 781 例死亡(其中 173 例因 CRC 死亡)。诊断后摄入量和 CRC 特异性死亡率的多变量调整 HR 分别为每天每 1 份 SSB(份/天)1.21(95% CI:0.87–1.68)和每 20 克 1.24(95% CI:0.95–1.63)每天果糖。主要在诊断后≤5年内观察到与CRC特异性死亡率的显着正相关(每1份SSB/天的HR = 1.59,95% CI:1.06-2.38)。在 ASB 与 CRC 特异性死亡率和全因死亡率之间观察到显着的负相关(≥5 份与 <1 份/周的 HR 分别为 0.44,95% CI:0.26–0.75 和 0.70,95% CI:0.55–0.89) 。

 结论


诊断后摄入较高的 SSB 和糖可能与较高的 CRC 特异性死亡率相关,但仅在诊断后 5 年内,此时因 CRC 导致的死亡较多。 ASB 与 CRC 特异性死亡率之间的负相关关系值得进一步研究。

更新日期:2021-07-15
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