Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival,British Journal of Cancer

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Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival
British Journal of Cancer ( IF 6.4 ) Pub Date : 2021-07-15 , DOI: 10.1038/s41416-021-01487-7
Emilie S Zoltick ₁ , Stephanie A Smith-Warner _{2,

3} , Chen Yuan ₄ , Molin Wang _{3,

5,

6} , Charles S Fuchs _{7,

8} , Jeffrey A Meyerhardt ₄ , Andrew T Chan _{6,

9,

10,

11} , Kimmie Ng ₄ , Shuji Ogino _{3,

4,

10,

12} , Meir J Stampfer _{2,

3,

6} , Edward L Giovannucci _{2,

3,

6} , Kana Wu ₂

Affiliation

Center for Healthcare Research in Pediatrics, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Yale Cancer Center, New Haven, CT, USA.
Genentech, San Francisco, CA, USA.
Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Background

The influence of a high sugar diet on colorectal cancer (CRC) survival is unclear.

Methods

Among 1463 stage I–III CRC patients from the Nurses’ Health Study and Health Professionals Follow-up Study, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC-specific and all-cause mortality in relation to intake of post-diagnosis sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB), fruit juice, fructose and other sugars.

Results

Over a median 8.0 years, 781 cases died (173 CRC-specific deaths). Multivariable-adjusted HRs for post-diagnosis intake and CRC-specific mortality were 1.21 (95% CI: 0.87–1.68) per 1 serving SSBs per day (serving/day) and 1.24 (95% CI: 0.95–1.63) per 20 grams fructose per day. Significant positive associations for CRC-specific mortality were primarily observed ≤5 years from diagnosis (HR per 1 serving/day of SSBs = 1.59, 95% CI: 1.06–2.38). Significant inverse associations were observed between ASBs and CRC-specific and all-cause mortality (HR for ≥5 versus <1 serving/week = 0.44, 95% CI: 0.26–0.75 and 0.70, 95% CI: 0.55–0.89, respectively).

Conclusions

Higher post-diagnosis intake of SSBs and sugars may be associated with higher CRC-specific mortality, but only up to 5 years from diagnosis, when more deaths were due to CRC. The inverse association between ASBs and CRC-specific mortality warrants further examination.

中文翻译：

含糖饮料、人工甜味剂饮料和糖摄入量与结直肠癌生存率

背景

高糖饮食对结直肠癌（CRC）生存的影响尚不清楚。

方法

在来自护士健康研究和健康专业人员随访研究的 1463 名 I-III 期 CRC 患者中，我们估计了 CRC 特异性死亡率和全因死亡率与摄入量相关的风险比 (HR) 和 95% 置信区间 (CI)诊断后含糖饮料（SSB）、人工甜味饮料（ASB）、果汁、果糖和其他糖。

结果

中位 8.0 年期间，有 781 例死亡（其中 173 例因 CRC 死亡）。诊断后摄入量和 CRC 特异性死亡率的多变量调整 HR 分别为每天每 1 份 SSB（份/天）1.21（95% CI：0.87–1.68）和每 20 克 1.24（95% CI：0.95–1.63）每天果糖。主要在诊断后≤5年内观察到与CRC特异性死亡率的显着正相关（每1份SSB/天的HR = 1.59，95% CI：1.06-2.38）。在 ASB 与 CRC 特异性死亡率和全因死亡率之间观察到显着的负相关（≥5 份与 <1 份/周的 HR 分别为 0.44，95% CI：0.26–0.75 和 0.70，95% CI：0.55–0.89）。