Food loss and waste (FLW) hampers global food security, human health and environmental sustainability. However, monitoring and benchmarking FLW reduction is often constrained by the lack of reliable and consistent data, especially for emerging economies. Here we use 6 yr large-scale field surveys and literature data to quantify the FLW of major agrifood products along the entire farm-to-fork chain in China. We show that 27% of food annually produced for human consumption in the country (349 ± 4 Mt) is lost or wasted; 45% of this is associated with postharvest handling and storage and 13% with out-of-home consumption activities. We also show that the land, water, carbon, nitrogen and phosphorus footprints associated with total FLW are similar to those of a medium-sized country (such as the United Kingdom’s in the case of carbon footprint). These results highlight the importance of better primary data to inform FLW reduction actions and ensure food security and sustainability.