Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.

中文翻译：

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完整的低血糖反调节需要瘦素受体信号传导：一项针对雄性 Zucker 大鼠的研究

低血糖是糖尿病患者临床管理的主要障碍。新出现的证据支持瘦素在门控低血糖反调节中的作用。这项工作表明，雄性瘦素受体无效 Zucker (fa/fa) 大鼠在低血糖反调节方面表现出严重损伤。因此，增加瘦素水平可能具有预防低血糖症的临床效用。