当前位置: X-MOL 学术Curr. Eye Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Elevated Serum Immunoglobulin E Levels are Associated with the Severity of Newly Diagnosed, Acute Vogt–Koyanagi–Harada Disease
Current Eye Research ( IF 1.7 ) Pub Date : 2021-07-19 , DOI: 10.1080/02713683.2021.1951299
Huiying Ji 1 , Nan Zhang 2 , Maoli Zhu 2 , Jianhong Dong 2 , Zhijian Jiang 2
Affiliation  

ABSTRACT

Objective

To investigate the correlation between serum immunoglobulin E (IgE) levels and severity of Vogt–Koyanagi–Harada (VKH) disease.

Methods

The medical records of patients with VKH disease between 2015 and 2020 were reviewed. Serum immunoglobulins (IgA, IgE, IgG, and IgM), tumor necrosis factor α (TNFα) and C-reactive protein (CRP) were measured. Patients were divided into IgE-positive (IgE ≥ 100 IU/mL) and IgE-negative (IgE < 100 IU/mL) groups. The best-corrected visual acuity (BCVA) and macular morphologic characteristics including foveal thickness (FT), serous retinal detachment (SRD), sensory retinal thickness (SRT), central foveal thickness (CFT), cube volume (V), and cube average thickness (AT) were determined in patients in both groups.

Results

Of 128 patients included in the study, 35 (27.34%) patients were IgE-positive, BCVA (logMAR) was worse in the IgE-positive group. The mean CRP (P= .012) and TNFα (P≤ 0.001) levels were greater in the IgE-positive group than in the IgE-negative group. Regarding macular morphologic characteristics, FT (P= .010), SDR (P= .004), CFT (P= .008), V (P= .013), and AT (P= .006) were significantly greater in the IgE-positive group than in the IgE-negative group.

Conclusions

Elevated serum IgE levels were associated with more severe macular changes in patients with VKH disease. These findings suggest that IgE may be involved in the progression of VKH disease.



中文翻译:

血清免疫球蛋白 E 水平升高与新诊断的急性 Vogt–Koyanagi–Harada 病的严重程度相关

摘要

客观的

研究血清免疫球蛋白 E (IgE) 水平与 Vogt-Koyanagi-Harada (VKH) 病严重程度之间的相关性。

方法

回顾了2015-2020年VKH病患者的病历。测量了血清免疫球蛋白(IgA、IgE、IgG 和 IgM)、肿瘤坏死因子 α(TNFα)和 C 反应蛋白(CRP)。患者分为IgE阳性(IgE≥100 IU/mL)和IgE阴性(IgE < 100 IU/mL)组。最佳矫正视力 (BCVA) 和黄斑形态特征,包括中心凹厚度 (FT)、浆液性视网膜脱离 (SRD)、感觉视网膜厚度 (SRT)、中央中心凹厚度 (CFT)、立方体积 (V) 和立方平均值测定两组患者的厚度(AT)。

结果

在纳入研究的 128 名患者中,35 名 (27.34%) 患者为 IgE 阳性,IgE 阳性组的 BCVA (logMAR) 更差。IgE 阳性组的平均 CRP ( P = .012) 和 TNFα ( P ≤ 0.001) 水平高于 IgE 阴性组。关于黄斑形态学特征,FT ( P = .010)、SDR ( P = .004)、CFT ( P = .008) 、V ( P = .013) 和 AT ( P = .006)在IgE阳性组高于IgE阴性组。

结论

血清 IgE 水平升高与 VKH 病患者更严重的黄斑改变有关。这些发现表明 IgE 可能参与了 VKH 疾病的进展。

更新日期:2021-07-19
down
wechat
bug