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Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer
Current Oncology ( IF 2.6 ) Pub Date : 2021-01-13 , DOI: 10.3390/curroncol28010046
Sidra Javed

Prostate cancer can masquerade as just normocytic anemia and thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or tumor lysis syndrome (TLS). We are reporting an intriguing case of metastatic prostate cancer which remained undiagnosed until the patient showed signs of tumor lysis syndrome (TLS), leading to urate nephropathy requiring urgent hemodialysis. Tumor lysis syndrome is an oncological emergency but an exceedingly rare complication in non-hematological malignancies, including prostate cancer. It is challenging to recognize features of TLS in a case such as this with an unknown diagnosis. In the case of an established diagnosis of malignancy, however, checking baseline renal function, uric acid, lactate dehydrogenase (LDH), potassium, and phosphate to monitor for TLS as well as considering urate lowering therapy can help prevent adverse outcomes.

中文翻译:

一例前列腺癌未确诊病例中肿瘤溶解综合征引起的尿酸盐肾病

前列腺癌可以伪装成正细胞性贫血和血小板减少症、血栓性血小板减少性紫癜 (TTP)、溶血性尿毒症综合征 (HUS) 或肿瘤溶解综合征 (TLS)。我们报告了一个有趣的转移性前列腺癌病例,该病例在患者出现肿瘤溶解综合征 (TLS) 的迹象之前仍未确诊,导致尿酸盐肾病需要紧急血液透析。肿瘤溶解综合征是一种肿瘤急症,但在非血液系统恶性肿瘤(包括前列腺癌)中是一种极为罕见的并发症。在这种诊断未知的情况下识别 TLS 的特征是具有挑战性的。然而,在确诊为恶性肿瘤的情况下,检查基线肾功能、尿酸、乳酸脱氢酶 (LDH)、钾、
更新日期:2021-01-13
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